Completed projects

Visceral leishmaniasis

Aminopyrazoles

Cutaneous leishmaniasis

Anfoleish (CL)

Pandemic Preparedness

ANTICOV

Cutaneous leishmaniasis, Malaria, Sleeping sickness, Visceral leishmaniasis, Chagas disease

Antiprotozoal activity profiling of approved drugs: a starting point toward drug repositioning

Chagas disease

Azoles E1224

Visceral leishmaniasis

Celgene Global Health visceral leishmaniasis series 1

Visceral leishmaniasis

CF series

Chagas disease

Chagas C205 series

Visceral leishmaniasis

Daiichi Sankyo Hit-to-lead for leishmaniasis

Chagas disease

Daiichi Sankyo series

Visceral leishmaniasis

Development and validation of a novel Leishmania screening cascade

Malaria, Sleeping sickness, Visceral leishmaniasis, Chagas disease

DNDi Screening of the MMV Open Access Malaria Box for HAT, VL, and Chagas disease

Visceral leishmaniasis

DNDI-5421 & DNDI-5610

Visceral leishmaniasis

DNDI-5561

Chagas disease

Fenarimol

Chagas disease

Fexinidazole for Chagas

Visceral leishmaniasis

Fexinidazole/Miltefosine Combination (VL)

River blindness

Flubendazole Macrofilaricide

River blindness

Flubentylosin

Visceral leishmaniasis

Generic AmBisome

Visceral leishmaniasis

GSK245 (DDD1305143)

Disease Type

Guides to free computational chemistry tools for drug discovery

Disease Type

Hepatitis C PACT

Hepatitis C

Screening in Malaysia

Pandemic Preparedness

Hit-to-lead broad-spectrum antivirals for COVID-19

Sleeping sickness, Visceral leishmaniasis, Chagas disease

iNTRODB

Chagas disease

K777 (Chagas)

Visceral leishmaniasis

Leishmaniasis hit-to-lead

Visceral leishmaniasis

Leishmaniasis L205 series

Chagas disease

Nitroimidazole (Chagas)

Visceral leishmaniasis, Chagas disease

NTD Drug Discovery Booster Hit-to-lead

Chagas disease

Oxachagas

Cutaneous leishmaniasis, River blindness, Malaria, Sleeping sickness, Visceral leishmaniasis, Chagas disease

Pathogen Box

Pandemic Preparedness

Pre-clinical support for COVID-19

Chagas disease

Screening and lead optimization of new compounds for Chagas disease

River blindness

Screening Filarial disease

Visceral leishmaniasis

Screening leishmaniasis

Sleeping sickness

SCYNEXIS Inc. as part of the DNDi HAT Lead Optimization Consortium

Sleeping sickness

SCYX-1330682 & SCYX-1608210 oxaboroles

Sleeping sickness

SCYX-2035811

Cutaneous leishmaniasis, River blindness, Malaria, Mycetoma, Sleeping sickness, Visceral leishmaniasis, Chagas disease

Source data from neglected disease R&D pipeline review

Visceral leishmaniasis

Successful screening collaboration leads to a new lead optimization project

Chagas disease

Two series of fenarimols for the treatment of Chagas disease

Visceral leishmaniasis

VL-0208

Visceral leishmaniasis

VL-2098

Sleeping sickness

WEHI Library – Screening identifies new compounds for HAT