Completed projects

Visceral leishmaniasis

Aminopyrazoles

Cutaneous leishmaniasis

Anfoleish (CL)

Pandemic Preparedness

ANTICOV

Cutaneous leishmaniasis, Malaria, Sleeping sickness, Chagas disease, Visceral leishmaniasis

Antiprotozoal activity profiling of approved drugs: a starting point toward drug repositioning

Chagas disease

Azoles E1224

Visceral leishmaniasis

Celgene Global Health visceral leishmaniasis series 1

Visceral leishmaniasis

CF series

Chagas disease

Chagas C205 series

Visceral leishmaniasis

Daiichi Sankyo Hit-to-lead for leishmaniasis

Chagas disease

Daiichi Sankyo series

Visceral leishmaniasis

Development and validation of a novel Leishmania screening cascade

Chagas disease, Malaria, Sleeping sickness, Visceral leishmaniasis

DNDi Screening of the MMV Open Access Malaria Box for HAT, VL, and Chagas disease

Visceral leishmaniasis

DNDI-5421 & DNDI-5610

Visceral leishmaniasis

DNDI-5561

Chagas disease

Fenarimol

Chagas disease

Fexinidazole for Chagas

Visceral leishmaniasis

Fexinidazole/Miltefosine Combination (VL)

Filaria: river blindness

Flubendazole Macrofilaricide

Filaria: river blindness

Flubentylosin

Visceral leishmaniasis

Generic AmBisome

Disease Type

Guides to free computational chemistry tools for drug discovery

Disease Type

Hepatitis C PACT

Hepatitis C

Screening in Malaysia

Pandemic Preparedness

Hit-to-lead broad-spectrum antivirals for COVID-19

Sleeping sickness, Chagas disease, Visceral leishmaniasis

iNTRODB

Chagas disease

K777 (Chagas)

Visceral leishmaniasis

Leishmaniasis hit-to-lead

Visceral leishmaniasis

Leishmaniasis L205 series

Chagas disease

Nitroimidazole (Chagas)

Chagas disease, Visceral leishmaniasis

NTD Drug Discovery Booster Hit-to-lead

Chagas disease

Oxachagas

Cutaneous leishmaniasis, Filaria: river blindness, Malaria, Sleeping sickness, Chagas disease, Visceral leishmaniasis

Pathogen Box

Pandemic Preparedness

Pre-clinical support for COVID-19

Chagas disease

Screening and lead optimization of new compounds for Chagas disease

Filaria: river blindness

Screening Filarial disease

Sleeping sickness

SCYNEXIS Inc. as part of the DNDi HAT Lead Optimization Consortium

Sleeping sickness

SCYX-1330682 & SCYX-1608210 oxaboroles

Sleeping sickness

SCYX-2035811

Cutaneous leishmaniasis, Filaria: river blindness, Malaria, Mycetoma, Sleeping sickness, Chagas disease, Visceral leishmaniasis

Source data from neglected disease R&D pipeline review

Visceral leishmaniasis

Successful screening collaboration leads to a new lead optimization project

Chagas disease

Two series of fenarimols for the treatment of Chagas disease

Visceral leishmaniasis

VL-0208

Visceral leishmaniasis

VL-2098

Sleeping sickness

WEHI Library – Screening identifies new compounds for HAT