Test the efficacy and safety of treatments in mild to moderate COVID-19 patients in low-resource settings
current phase of drug development
updated 15 Nov 2021
The ANTICOV clinical trial responds to the urgent need to identify treatments that can be used to treat mild and moderate cases of COVID-19 early and prevent spikes in hospitalizations that could overwhelm fragile and already overburdened health systems in low- and middle-income countries.
Launched in November 2020 by the ANTICOV consortium, the study is an open-label, randomised, comparative, ‘adaptive platform trial’ that is testing the safety and efficacy of treatments in mild-to-moderate COVID-19 patients. ANTICOV aims to identify early treatments that can prevent progression of COVID-19 to severe disease and potentially limit transmission.
An adaptive platform trial is a flexible and innovative trial design that allows for treatments to be added or removed as evidence emerges.
ANTICOV researchers are actively looking to select the most promising treatments from ongoing global scientific efforts with proof of efficacy, in collaboration with the Access to COVID-19 Tools Accelerator (ACT-A) Therapeutics Partnership, co-convened by Unitaid and Wellcome on behalf of the COVID-19 Therapeutics Accelerator.
Major funding for the ANTICOV consortium is provided by the German Federal Ministry of Education and Research (BMBF) through KfW and by the global health agency Unitaid as part of ACT-A. Early support to launch the initiative was provided by the European & Developing Countries Clinical Trials Partnership (EDCTP), under its second programme supported by the European Union with additional funding from the Swedish government, and the Starr International Foundation, Switzerland.
- ANTICOV website
- Master protocol
- Patient information and consent form
- Standard operating procedures and other resources
News and stories
- 30 July 2021 – ‘A clear demonstration of the capacity in Africa to conduct extremely complex studies’ – Dr John Amuasi on the ANTICOV trial in Ghana
- 29 July 2021 – Recruitment begins in Mozambique for ANTICOV clinical trial of early treatments for COVID-19
- 28 June 2021 – Why Mali joined the ANTICOV clinical trial: A conversation with Dr Samba Sow
- 18 June 2021 – A few moments with an ANTICOV investigator: Dr Bernhards Ogutu in Kenya
- 27 April 2021 – ANTICOV: largest clinical trial in Africa for people with mild COVID-19 to test new drug combination
- 24 November 2020 – Largest clinical trial in Africa to treat COVID-19 cases before they become severe is launched in 13 countries
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