Our world class studies take place mostly in remote settings
At DNDi, we work with research partners from around the world to evaluate new and improved medicines and treatment regimens in clinical trials. The evidence from these studies enables us to deliver better, more affordable treatments for the most neglected.
We conduct world-class clinical trials following Good Clinical Practice standards even in the most remote and rural areas. This involves infrastructure updates and training for clinical staff, often through regional disease-specific research networks supported by DNDi. We also screen and treat people for various diseases, regardless of whether they end up being included in our clinical trials.
‘To ensure [our trials] were Good Clinical Practice compliant, we needed to strengthen capacities in terms of infrastructure and expertise. These improvements will be useful to the Congolese research community and should last for future studies.’
Dr Crispin Lumbala, former Director, National Sleeping Sickness Control Programme, DRC
Networked research groups build capacity and increase research quality
Since 2003, DNDi has supported the creation of four disease-specific clinical research ‘platforms’ that bring together key actors including health ministries, national disease control programmes, regulatory authorities, WHO, academia, civil society groups, and clinicians and other health professionals.
The platforms serve as ‘knowledge hubs’ that:
- help identify patients’ needs and R&D gaps,
- strengthen and sustain clinical research capacity,
- facilitate access to new treatments, and
- advocate for an enabling policy and regulatory environment for needs-driven R&D.
Clinical trial data transparency
DNDi recognizes the value to researchers in public health, and other actors, of sharing and disseminating our clinical data. Sharing responsibly can contribute to knowledge for the improvement of the lives of neglected patients whose needs are often overlooked as research priorities.
We are committed to sharing our clinical trial data in a way that respects participants in medical research and maximizes the benefits to participants and society, while minimizing any potential harm.
- In 2017, we signed the World Health Organization’s Joint statement on public disclosure of results from clinical trials
- You can read more about our commitment to data sharing in DNDi’s Policy on Sharing and Secondary Use of Human Subject Research Data.
- Researchers who would like access to DNDi clinical data are requested to fill out a request form: PDF Please send completed forms or inquiries to: CTdata@dndi.org
DNDi is sponsoring or collaborating on clinical trials taking place across 5 continents and 8 disease areas.
Combining existing treatments to improve patient outcomes. Preliminary results from our Phase II trial in Peru and Colombia showed better outcomes combining thermotherapy and miltefosine compared to treatment with thermotherapy alone. A Phase III study is now planned in four countries in Latin America.
A radical boost for sustainable elimination. This single-dose sleeping sickness treatment could be a true game-changer for people at risk of this deadly disease.
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