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  • DNDi_Logo_No-Tagline_Full Colour
  • Our work
    • Diseases
      • Sleeping sickness
      • Visceral leishmaniasis
      • Cutaneous leishmaniasis
      • Chagas disease
      • Parasitic worms
      • Mycetoma
      • Dengue
      • Paediatric HIV
      • Cryptococcal meningitis
      • Hepatitis C
      • Pandemic preparedness
      • Antimicrobial resistance
    • Research & development
      • R&D portfolio & list of projects
      • Drug discovery
      • Translational research
      • Clinical trials
      • Registration & access
      • Evidence for impact
      • Treatments delivered
    • Advocacy
      • Open and collaborative R&D
      • Transparency of R&D costs
      • Pro-access policies and IP
      • Children’s health
      • Gender equity
      • Climate change
      • AI and new technologies
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    • Partnerships
      • Our partners
      • Partnering with us
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      • Chagas Platform
      • Dengue Alliance
      • HAT Platform
      • LEAP Platform
      • redeLEISH Network
    • DNDi worldwide
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      • DNDi Eastern Africa
      • DNDi Japan
      • DNDi Latin America
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      • DNDi South Asia
      • DNDi South-East Asia
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Home

Research and development

We put neglected communities at the heart of drug R&D

Home

Research and development

We put neglected communities at the heart of drug R&D

Advancing medical innovation from laboratory bench to patient bedside

Our teams have been working since 2003 to address gaps in the traditional biomedical R&D system that lead to serious unmet medical needs for neglected patients. Acting as a ‘conductor of a virtual orchestra’, DNDi collaborates with research partners around the world at all stages of the R&D process. Together, we’ve discovered, developed, and delivered new treatments that reduce illness, suffering, and death from some of the world’s most neglected diseases.

Drug discovery

Translational research

Clinical trials

Registration and access

Evidence for impact

Project portfolio

We are working on more than 40 research and treatment access projects, including 21 focused on identifying or developing new chemical entities.

see portfolio

Treatments delivered

We have delivered seventeen new treatments for six deadly diseases, saving millions of lives.

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Scientific articles

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Scientific articles
9 Oct 2026

A Perspective on Biomarkers, Candidates for Surrogate End Points to Accelerate Successful Development of New Antiparasitic Agents for the Treatment of Chronic Chagas Disease

ACS Infectious Diseases
Scientific articles
5 Oct 2026

Winning the endgame against sleeping sickness: Efficacy profiling of acoziborole against African trypanosomes with the focus on Trypanosoma brucei rhodesiense

PLoS Neglected Tropical Diseases
Scientific articles
22 Sep 2026

Efficacy and safety of alternative benznidazole and nifurtimox regimens for adults with chronic Trypanosoma cruzi infection (TESEO): an open-label, randomised, non-inferiority phase 2b trial

The Lancet Infection Diseases
Scientific articles
19 Sep 2026

Thermotherapy compared with intralesional sodium stibogluconate for Leishmania aethiopica cutaneous Leishmaniasis in Ethiopia: A phase II randomized controlled trial

BMC Medicine
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Target product profiles (TPPs)

TPPs serve to ensure that all products are designed from the start for the people and places that need them by describing the ideal specifications needed for a treatment.

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Events

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10-13 November 2026

Madrid, Spain

21st International Congress on Infectious Diseases (ICID 2026)

6-9 December 2026

Rio de Janeiro, Brazil

Atlantic Basin Conference on Chemistry

16 November 2026

Durham, North Carolina, USA

Eliminating Sleeping Sickness: Celebrating North Carolina Innovation

27-29 November 2026

Saitama, Japan

Joint congress on global health 2026 (67th Annual meeting of the Japanese Society of Tropical Medicine)

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