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  • Our work
    • Diseases
      • Sleeping sickness
      • Visceral leishmaniasis
      • Cutaneous leishmaniasis
      • Chagas disease
      • Parasitic worms
      • Mycetoma
      • Dengue
      • Paediatric HIV
      • Cryptococcal meningitis
      • Hepatitis C
      • Pandemic preparedness
      • Antimicrobial resistance
    • Research & development
      • R&D portfolio & list of projects
      • Drug discovery
      • Translational research
      • Clinical trials
      • Registration & access
      • Evidence for impact
      • Treatments delivered
    • Advocacy
      • Open and collaborative R&D
      • Transparency of R&D costs
      • Pro-access policies and IP
      • Children’s health
      • Gender equity
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      • AI and new technologies
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      • Our partners
      • Partnering with us
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      • Dengue Alliance
      • HAT Platform
      • LEAP Platform
      • redeLEISH Network
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      • DNDi Eastern Africa
      • DNDi Japan
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Home

Research and development

We put neglected communities at the heart of drug R&D

Home

Research and development

We put neglected communities at the heart of drug R&D

Advancing medical innovation from laboratory bench to patient bedside

Our teams have been working since 2003 to address gaps in the traditional biomedical R&D system that lead to serious unmet medical needs for neglected patients. Acting as a ‘conductor of a virtual orchestra’, DNDi collaborates with research partners around the world at all stages of the R&D process. Together, we’ve discovered, developed, and delivered new treatments that reduce illness, suffering, and death from some of the world’s most neglected diseases.

Drug discovery

Translational research

Clinical trials

Registration and access

Evidence for impact

Project portfolio

We are working on more than 40 research and treatment access projects, including 21 focused on identifying or developing new chemical entities.

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Treatments delivered

We have delivered fourteen new treatments for six deadly diseases, saving millions of lives.

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Scientific articles

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Scientific articles
22 Jun 2026

What Is in a Structure? Cell Permeability and Solubility of Series of Macrocycles and Linear Matched Pairs

Journal of Medicinal Chemistry
Scientific articles
5 Jun 2026

Severe visceral leishmaniasis in Ethiopia: Outcomes, co-infections and mortality in a prospective real-world cohort

PLOS Neglected Tropical Diseases
Scientific articles
29 May 2026

From invisibility to political power: Policy lessons from a decade of Brazil’s Social Forum for Infectious and Neglected Diseases

PLOS Neglected Tropical Diseases
Scientific articles
14 May 2026

In vitro profiling of Trypanosoma cruzi inhibitors identified from high throughput screening and application to parasite painting

International Journal for Parasitology: Drugs and Drug Resistance
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Target product profiles (TPPs)

TPPs serve to ensure that all products are designed from the start for the people and places that need them by describing the ideal specifications needed for a treatment.

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Events

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16-19 August 2026

Brásilia, Bresil

61st Congress of the Brazilian Society of Tropical Medicine (Medtrop)

16-21 August 2026

Montréal, Canada

ICOPA 202616th International Congress of Parasitology

22-25 June 2026

Dublin, Ireland

EFMC-ACSMEDI Medicinal Chemistry Frontiers 2026

19 May 2026

Geneva, Switzerland and online

Strengthening global health financing through digital infrastructure: Introducing HealthFund Hub

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International non-profit developing safe, effective, and affordable treatments for the most neglected patients.

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