DNDi started its activities in South Asia in 2004 to build and strengthen regional partnerships to carry out R&D for neglected diseases in the region. DNDi has activities in India and Bangladesh, mainly focused on visceral leishmaniasis and conducting clinical trials and capacity-building initiatives. More recently, DNDi South Asia started to be active in the fields of paediatric HIV and early drug discovery for leishmaniasis.
Supported the Indian National Kala-azar Elimination Programme in building capacity to diagnose kala-azar (visceral leishmaniasis) and post-kala-azar dermal leishmaniasis (PKDL), and by gathering evidence needed to respond to threats to the sustainable elimination of visceral leishmaniasis in the region.
Completed recruitment for a clinical trial for PKDL, testing amphotericin B monotherapy and an amphotericin B -miltefosine combination, with results expected by mid-2020.
Partnered in an MSF study on kala-azar-HIV co-infection in Bihar state to evaluate treatments with amphotericin B monotherapy and an amphotericin B -miltefosine combination, with results expected in 2019 that will provide key evidence to national and regional decision-makers on the best treatment for co-infected patients.
Launched GARDP’s 11-country observational study to collect clinical information on treatment of babies with sepsis, to guide the development of new and improved antibiotic treatments for newborns.
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