DNDi and Novartis initiated a collaboration and licence agreement in early 2020 to jointly develop LXE408 – a first-in-class compound, discovered at Novartis with financial support from Wellcome – as a potential new oral treatment for visceral leishmaniasis.

Project updates

2021

A Phase I multiple ascending dose study of LXE408 was completed in September 2021, when the last visit of the last participant was completed. All results are expected in the first quarter of 2022. The compound showed good tolerability in Phase I, supporting the continuation of the clinical study to Phase II. Preparation is underway to initiate a Phase II study with participants with visceral leishmaniasis in India in 2022.

2020

A Phase I multiple ascending dose study of LXE408 began in 2020 but faced delays due to the COVID-19 pandemic. Results are expected in mid-2021. Planning is underway for a Phase II study to commence in India in 2022.