DNDi is supporting the ANTICOV clinical trial by identifying and validating repurposed drug candidates, beginning with the in vitro and in vivo experimental work needed to provide supporting pre-clinical evidence. We are focusing mainly on compounds that have a direct-acting antiviral profile and on combinations of antivirals and anti-inflammatories.

COVID-19 is a new disease and has several phases – from an initial viral stage to a later inflammatory stage – which contributes to a lack of consensus understanding of the translational value of in vitro and in vivo experimental models. To help overcome this knowledge gap, our discovery team is also working to expand the translational understanding of how data generated in pre-clinical in vitro and in vivo models can help to predict the future efficacy of investigational drug candidates in patients.

Project updates

2021

DNDi continued to offer pre-clinical support for the selection of new treatment arms in the ANTICOV trial. Additional compounds were assessed based on clinical and pre-clinical literature, including the new RdRp inhibitors (molnupiravir, AT-527) and MPro inhibitors (PF-07321332), with clinical data now being published. This project is both providing support to ANTICOV with pre-clinical evidence for the selection of clinical trial arms, as well as helping to define a clear path forward from in vitro data to in vivo efficacy assessment based on clear pharmacokinetic data and modelling. 

2020

In vivo experiments to obtain pre-clinical data on several known antivirals (ritonavir-boosted atazanavir, nitazoxanide, favipiravir, sofosbuvir, and daclatasvir) were started in November 2020 in collaboration with the Katholieke Universiteit Leuven, the Unité de Virus émergents at the Université d’Aix-Marseille, and the University of Liverpool. At least three more potential treatments will be investigated in 2021.