Maintain back-up drug candidate oxaboroles to replace the drug candidate acoziborole, if needed
current phase of drug development
updated 1 Jun 2021
To guard against possible problems with clinical development of the drug candidate acoziborole as a treatment for human African trypanosomiasis (HAT), commonly known as sleeping sickness, two back-up candidates from the same class have been identified as options for future development.
Extensive pharmacokinetic profiling of possible oxaborole compounds led to the selection of SCYX-1608210 and SCYX-1330682, which demonstrated cure in the Stage 2 mouse model for sleeping sickness. Given the current success of other projects for sleeping sickness, further development was put on hold in 2013 and will only recommence if needed.
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