Browse our clinical trial protocol synopses
- Filaria: river blindness
DNDI-TYL-01
Tylamac phase-II trial for treatment of onchocerciasis
- Democratic Republic of Congo, Africa
- Cutaneous leishmaniasis
DNDi-MILT-08-CL
Efficacy and safety of thermotherapy plus miltefosine for cutaneous leishmaniasis in South America
- Colombia, Latin America, Peru
- Hepatitis C
DNDi-RDV-04-HCV
Bioequivalence study of test and reference ravidasvir for chronic HCV (in healthy fed participants)
- Asia, Malaysia
- Sleeping sickness
DNDi-OXA-07-HAT
A drug-drug interaction study of acoziborole for T. b. gambiense sleeping sickness (in healthy male participants)
- Asia, Malaysia
- Sleeping sickness
DNDi-OXA-05-HAT
Pharmacokinetics, efficacy, safety, and tolerability of acoziborole in children with T. b. gambiense sleeping sickness
- Africa, Democratic Republic of Congo
- Sleeping sickness
DNDi-OXA-04-HAT
Safety and tolerability of acoziborole for seropositive non-parisitologically confirmed T. b. gambiense sleeping sickness
- Africa, Democratic Republic of Congo, Guinea
- Visceral leishmaniasis
DNDi-MILT/PM-01-VL
Efficacy and safety of paromomycin plus miltefosine or sodium stibogluconate for visceral leishmaniasis in Africa
- Africa, Ethiopia, Kenya, Uganda, Sudan
- Visceral leishmaniasis
DNDi-LXE408-02-VL / CLXE408A12202R
Efficacy, safety and pharmacokinetics of LXE408 for primary visceral leishmaniasis in Ethiopia
- Africa, Ethiopia
- Visceral leishmaniasis
DNDi-LXE408-01-VL / CLXE408A12201R
Efficacy and safety of two LXE408 regimens for primary visceral leishmaniasis in India
- Asia, India
- Hepatitis C
DNDi-RDV-02-HCV
Bioequivalence study of test and reference ravidasvir tablets for chronic HCV (in healthy fed participants)
- Asia, Malaysia
- Chagas disease
DNDi-FEX-12-CH
Efficacy and safety of fexinidazole for undetermined chronic Chagas disease
- Europe, Spain
- Filaria: river blindness
DNDI-EMO-03
Tolerability, safety, and bioavailability study of immediate release emodepside for river blindness (in healthy participants)
- Europe, United Kingdom
- Filaria: river blindness
DNDI-EMO-02
Safety, tolerability, and pharmacokinetics of emodepside for river blindness (in healthy participants)
- Europe, United Kingdom
- Cutaneous leishmaniasis
DNDi-CpG-001
Safety, tolerability, pharmacokinetics, and pharmacodynamics of CpG ODN D35 for cutaneous leishmaniasis (in healthy participants)
- Europe, United Kingdom
- Cryptococcal meningitis
DNDi-5FC-02-CM
Bioavailability study of immediate release flucytosine for cryptococcal meningitis (in healthy fed participants)
- Africa, South Africa
- Cryptococcal meningitis
DNDi-5FC-01-CM
Bioavailability study of immediate release flucytosine for cryptococcal meningitis (in healthy fasting participants)
- Africa, South Africa
- Cutaneous leishmaniasis, Visceral leishmaniasis
DNDi-6148-01
Safety, tolerability, and pharmacokinetics of single dose DNDI-6148 for visceral leishmaniasis (in healthy participants)
- Europe, France
- Cutaneous leishmaniasis, Visceral leishmaniasis
DNDi‐0690‐02
Safety, tolerability, and pharmacokinetics of multiple dose DNDI-0690 for visceral leishmaniasis (in healthy participants)
- Europe, United Kingdom
- Visceral leishmaniasis
DNDi-0690-01
Safety, tolerability, and pharmacokinetics of single dose DNDI-0690 for visceral and cutaneous leishmaniasis (in healthy participants)
- Europe, United Kingdom
- Pandemic Preparedness
ANTICOV
Platform trial of efficacy and safety of several therapies for mild / moderate COVID-19
- Africa, Ghana, Guinea, Kenya, Sudan, Uganda, Mali, Brazil, Burkina Faso, Cameroon, Côte d’Ivoire, Democratic Republic of Congo, Ethiopia, Latin America, Tanzania, Mozambique
- Visceral leishmaniasis
DNDi-MILT COMB-02-PKDL
Efficacy and safety of miltefosine plus either liposomal amphotericin B or paromomycin for PKDL in Sudan
- Africa, Sudan
- Visceral leishmaniasis
DNDi-MILT COMB-01-PKDL
Efficacy and safety of liposomal amphotericin B alone and in combination with miltefosine for PKDL in Asia
- Asia, Bangladesh, India
- Mycetoma
DNDi-FOSR-04-MYC
Comparative efficacy of two fosravuconazole doses with itraconazole for eumycetoma, in combination with surgery
- Africa, Sudan
- Chagas disease
DNDi-CH-E1224-003
Efficacy and safety of shorter benznidazole regimens and E1224 for chronic Chagas disease
- Bolivia, Latin America
- Hepatitis C
DNDi-SOF/RDV-01-HCV
Efficacy, safety, tolerance, and pharmacokinetics of sofosbuvir plus ravidasvir for chronic HCV
- Asia, Thailand, Malaysia
- Sleeping sickness
DNDi-OXA-03-HAT
Absorption, metabolism, and excretion of acoziborole for sleeping sickness (in healthy participants)
- Europe, United Kingdom
- Sleeping sickness
DNDi-OXA-02-HAT
Efficacy and safety of acoziborole for T.b. gambiense sleeping sickness
- Africa, Democratic Republic of Congo, Guinea
- Sleeping sickness
DNDi-HAT-FEX-006
Efficacy and safety of fexinidazole for T. b. gambiense sleeping sickness in children
- Africa, Democratic Republic of Congo
- Sleeping sickness
DNDi-HAT-FEX-005
Efficacy and safety of fexinidazole for stage 1 & early stage 2 T. b. gambiense sleeping sickness
- Africa, Democratic Republic of Congo
- Sleeping sickness
DNDi-FEX-09-HAT
Efficacy, safety and adherence with fexinidazole for any stage of T.b. gambiense sleeping sickness
- Democratic Republic of Congo, Guinea, Africa
- Sleeping sickness
DNDi-FEX-07-HAT
Efficacy and safety of fexinidazole for T.b. rhodesiense sleeping sickness
- Africa, Uganda, Malawi
- Sleeping sickness
DNDi-FEX-004
Efficacy and safety of fexinidazole for late-stage T.b. gambiense sleeping sickness
- Africa
To request access to data from any of DNDi’s clinical trials, please visit the website of our data-sharing partner, Vivli, to make a data request.
Project portfolio
We are working on more than 40 research and treatment access projects, including 20 focused on identifying or developing new chemical entities.
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