We developed an easy-to-administer, strawberry-flavoured combination of four antiretroviral medicines to meet the needs of the youngest children, who are at the highest risk of dying without treatment. This new treatment was approved in South Africa in 2022 – the first country globally to grant regulatory approval for the 4-in-1 – followed by approvals in Mali, Uganda, and Kenya in early 2023.
The needs of children with HIV have long been neglected. While R&D efforts have succeeded in developing life-saving diagnosis and treatment innovations for adults, innovation for children has lagged far behind.
Until recently, the only treatments available for babies and kids were bitter-tasting, difficult to dose, and required refrigeration – making them unsuitable for children and their caregivers. Thankfully, new paediatric formulations are finally becoming available after decades of poor options. Our work is a key part of this revolution in paediatric HIV diagnosis and treatment.
‘The initial treatment was difficult to administer because of their bitter taste. Many times, Emmanuel would spit the medication instead of swallowing.’
What we have achieved
Our research is helping countries replace older, difficult–to–use, and sometimes ineffective formulations and scale up new, optimum treatments for young children.
New hope for children co-infected with HIV and TB. Drugs used to treat tuberculosis can interfere with HIV treatment, reducing its effectiveness. A successful study with our South African partners paved the way for better treatment for children living with both diseases.
A strawberry-flavoured, ‘4-in-1’ treatment for children. The 4-in-1 meets the treatment needs of the youngest children living with HIV. The combination of four antiretrovirals in easy-to-administer, heat-stable, strawberry-flavoured granules has been approved in South Africa
One of the largest paediatric HIV cohorts in the world. Our implementation study with over 1,000 children in Kenya, Uganda, and Tanzania was designed to help improve uptake of newer treatments for kids.
What we are doing for children living with HIV
Our engagement goes well beyond drug development alone. Through a series of partnerships, we are working to ensure improved treatments for kids are rolled out where they are needed most.
Paediatric HIV news & resources
Making medical history for neglected patients
We develop urgently needed treatments for neglected patients and ensure they’re affordable, available, and adapted to the communities who need them
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