The Open Synthesis Network (OSN) is a collaborative project that aims to engage master’s and undergraduate students in research for neglected diseases. Currently, the OSN includes 25 institutions from around the world.  

OSN participants have successfully delivered more than 400 new compounds for eight distinct DNDi projects in leishmaniasis, Chagas disease, mycetoma, and COVID-19. All successful compounds that come out of the OSN project will be further evaluated as part of DNDi’s discovery pipeline. 

How the Open Synthesis Network works

DNDi shares data on existing compounds from the relevant research projects with university participants, along with a list of new, ‘wanted’ chemical compounds. Students then explore the existing data, learn about the design rationale for the new compounds through open discussions with DNDi experts, and carry out the synthesis for one or more of these wanted compounds as part of their lab training. Students can use the data to design their own new compounds. DNDi tests all new compounds for relevant anti-infective activity, sharing the results openly with all OSN participants.

‘This partnership will contribute to real-life medicinal chemistry projects featuring neglected disease research. By participating in the OSN project, our students will get an opportunity to enhance their skills in medicinal chemistry research and will develop an interest to work on real drug discovery projects.’

Dr Kapil Juvale, Assistant Professor, Narsee Monjee Institute of Management Studies, India

Intellectual property

All work generated by OSN will be published in the public domain in real-time and remain free of intellectual property.

How to get involved

The online nature of OSN readily allows DNDi to open this collaboration to any universities interested in participating. To get involved, please contact Ben Perry: bperry@dndi.org

Follow OSN on Twitter: @OpenSynth

Open synthesis network infographic explaining the what, the why and the how

Project updates

2020

Four new projects were launched by the OSN in 2020, including OSN’s participation in the global COVID Moonshot initiative. The OSN website was revised to increase ease of data access.