Engage master’s and undergraduate students in research for neglected diseases.
current phase of drug development
updated 11 Nov 2022
The Open Synthesis Network (OSN) is a collaborative project that aims to engage master’s and undergraduate students in research for neglected diseases. Currently, the OSN includes 25 institutions from around the world.
OSN participants have successfully delivered more than 500 new compounds for eight distinct DNDi projects in leishmaniasis, Chagas disease, mycetoma, and COVID-19. All successful compounds that come out of the OSN project will be further evaluated as part of DNDi’s discovery pipeline.
How the Open Synthesis Network works
DNDi shares data on existing compounds from the relevant research projects with university participants, along with a list of new, ‘wanted’ chemical compounds. Students then explore the existing data, learn about the design rationale for the new compounds through open discussions with DNDi experts, and carry out the synthesis for one or more of these wanted compounds as part of their lab training. Students can use the data to design their own new compounds. DNDi tests all new compounds for relevant anti-infective activity, sharing the results openly with all OSN participants.
Dr Kapil Juvale, Assistant Professor, Narsee Monjee Institute of Management Studies, India
This partnership will contribute to real-life medicinal chemistry projects featuring neglected disease research. By participating in the OSN project, our students will get an opportunity to enhance their skills in medicinal chemistry research and will develop an interest to work on real drug discovery projects.
All work generated by OSN will be published in the public domain in real-time and remain free of intellectual property.
How to get involved
The online nature of OSN readily allows DNDi to open this collaboration to any universities interested in participating. To get involved, please contact Luiza Cruz: firstname.lastname@example.org
Follow OSN on Twitter: @OpenSynth
News & resources
- 29 June 2022 - How we came to start the Open Synthesis Network, The Medicine Maker
- 2 May 2022 - Open source, open science, The Medicine Maker
- 3 March 2022 - Open Synthesis Network research in an undergraduate laboratory: Development of benzoxazole amide derivatives against leishmania parasite, Journal of Chemical Education
- 8 January 2018 - Open Synthesis Network factsheet
- 13 June 2017 - Tapping student potential: Q&A on DNDi’s Open Synthesis Network with Ben Perry, Global Health NOW
- 3 May 2017 - New open source project engages universities in neglected diseases drug discovery
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