Use open data and collaborative methods to discover molecules that could lead to new medicines for mycetoma
current phase of drug development
updated 28 Apr 2023
The Mycetoma Open Source project (MycetOS) uses an ‘open source pharma’ approach to discover new treatments targeting M. mycetomatis, the predominant causative agent of fungal mycetoma (eumycetoma).
MycetOS was launched in 2018 by the University of Sydney, Australia, Erasmus MC (Erasmus University Medical Center, Rotterdam, the Netherlands), and DNDi.
MycetOS progresses drug discovery efforts through community-driven, in-kind scientific contributions and a robust, fully transparent online presence. All ideas and results are published immediately in real time to an open-access database, free of intellectual property constraints through the use of a Creative Commons licence. Results and the associated data form the starting point for the MycetOS community, which shares data and key project files on the GitHub platform and communicates on Twitter (@MycetOS).
Using this radically open approach, MycetOS aims to identify potential new treatments in a transparent and inclusive way.
How to get involved
To get involved, please join a monthly online research meeting on the GitHub platform.
For further information, follow project communications on Twitter (@MycetOS).
News & resources
- 4 February 2022 – Screening the Pandemic Response Box identified benzimidazole carbamates, olorofim, and ravuconazole as promising drug candidates for the treatment of eumycetoma, PLOS Neglected Tropical Diseases
- 10 November 2021 – MycetOS: Harnessing the power of open source to develop treatments for a most neglected disease
- 9 May 2018 – Addressing the most neglected diseases through an open research model: the discovery of fenarimols as novel drug candidates for eumycetoma, PLOS Neglected Tropical Diseases
- 6 February 2018 – New open source drug discovery project aims to develop mycetoma treatment
- 1 January 2018 – MycetOS factsheet
- Data sharing and key project discussions may be found on github
- 12 April 2023 – PhD defense Wilson Lim: Managing mycetoma: Improving identification and the search for new treatment options
- 9 June 2022 – Identifying novel drugs with new modes of action for neglected tropical fungal skin diseases (fungal skinNTDs) using an Open Source Drug discovery approach, Expert Opinion on Drug Discovery
Associate Professor Wendy van de Sande from Erasmus University, Rotterdam, Netherlands; Associate Professor Mat Todd at the University of Sydney, Australia; Ben Perry at DNDi.
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