Logo MycetOS project

The Mycetoma Open Source project (MycetOS) uses an ‘open source pharma’ approach to discover new treatments targeting M. mycetomatis, the predominant causative agent of fungal mycetoma (eumycetoma).

MycetOS was launched in 2018 by the University of Sydney, Australia, Erasmus MC (Erasmus University Medical Center, Rotterdam, the Netherlands), and DNDi.

MycetOS progresses drug discovery efforts through community-driven, in-kind scientific contributions and a robust, fully transparent online presence. All ideas and results are published immediately in real time to an open-access database, free of intellectual property constraints. Results and the associated data form the starting point for the MycetOS community, which communicates on Twitter (@MycetOS), uses a dedicated forum (subreddit) for transparent interactive discussion, and shares data and key project files on the GitHub platform.

Using this radically open approach, MycetOS aims to identify potential new treatments in a transparent and inclusive way.

Infographic explaining the MycetOS project

Project updates

2020

In 2020, MycetOS improved web-based options for sharing and tracking data and contributions, and released their first newsletter to mark World NTD Day in January. The project also initiated biweekly drug discovery project meetings, which are open for all to attend. Additional hit starting points with potential against M. mycetomatis were identified via screening of the open-source Pandemic Response Box pioneered by MMV and DNDi.

2019

A list of current targets for Open Pharma project MycetOS has been compiled and opportunities given to researchers interested in working on them. Two participating institutions from the Open Synthesis Network have received preliminary data and are working to identify new compounds with potential activity against mycetoma.

News & publications

Factsheet

Screenshot MycetOS fact sheet

Open Source Mycetoma
2018

More information

  • Dedicated subreddit forum for transparent, interactive discussion
  • Data sharing and key project files will be shared on github

For further information, please contact Dr Ben Perry (bperry@dndi.org) or join the project communications on Twitter (@MycetOS).

Launch participants

Associate Professor Wendy van de Sande from Erasmus University, Rotterdam, Netherlands; Associate Professor Mat Todd at the University of Sydney, Australia; Ben Perry, Senior Discovery Manager, DNDi.