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Home > Diseases
COVID19 icon

Pandemic preparedness

Our R&D portfolio for pandemic preparedness

Home > Diseases
COVID19 icon

Pandemic preparedness

Our R&D portfolio for pandemic preparedness

  • Overview
  • Projects

What we have achieved

We engaged in collaborative drug discovery partnerships to develop affordable, effective new COVID-19 treatments. We also mobilized partners around the world, particularly in low- and middle-income countries, to build clinical trials networks, share knowledge, and conduct research with a particular focus on finding solutions for low-resource settings.

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Pandemic Preparedness Platform for Health and Emerging Infectious Response (PANTHER)

Preparing clinical infrastructure for the next pandemic. Along with partners, DNDi co-founded PANTHER to prepare and respond rapidly to pandemics on the African continent by providing the human, technical, scientific, and administrative infrastructure through a network of experienced African research centres.

Coalition for Equitable Research in Low Resource Settings (CERCLE)

A network for research in low- and middle-income countries. In 2020, DNDi co-launched CERCLE, a coalition of 900 researchers & research institutions aiming to accelerate research on infectious diseases of pandemic potential by ensuring the participation – and meeting the specific needs of low-resource settings.

Clinical trials

ANTICOV

A multi-country trials focusing on mild and moderate cases of COVID-19. Conducted across 29 clinical trial sites in 13 African countries and Brazil by 27 medical research organizations, the ANTICOV study tested treatments that could reduce the risk of hospitalization.

What we are doing for pandemic preparedness

We are using our experience in non-profit drug development and our partnerships with medical research institutions worldwide to prepare for future viral pandemics in low- and middle-income countries.

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Drug discovery

ASAP-0017445 (Moonshot ASAP)

Drug discovery

AViDD ASAP

Translational research

COVID Moonshot

Drug discovery

Nucleoside Booster

Drug discovery

Open Synthesis Network

Drug discovery

Pandemic Response Box

Drug discovery

TMEM16 series

our r&d portfolio

Building capacity, uniting expertise

Research platforms and consortiums that bring together researchers and strengthen research capacities in low- and middle-income countries are central to our virtual R&D model. 

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Partnering for patients

Collaboration is an essential part of how we work. We have forged a diverse range of alliances and research collaborations with over 200 partners in nearly 50 countries.

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Making medical history for neglected patients

We develop urgently needed treatments for neglected patients and ensure they’re affordable, available, and adapted to the communities who need them

Young boy sitting on a hospital bed being examined by a nurse

Chagas disease

Causes heart and vital organ damage, after people are bitten by blood-sucking bugs

We delivered the first-ever treatment for children; now we’re searching for new drug candidates and working to boost access to care

Patient medical examination

Cryptococcal meningitis

Without treatment, deadly for thousands of people with advanced HIV

We’re working to improve access to life-saving treatments and developing an easier-to-use formulation

Girl with skin lesions on her nose

Cutaneous leishmaniasis

Leaves disfiguring, life-long scars that lead to severe social stigma

We’re working to develop safer, shorter treatments for this disabling disease

Doctor with young patient in hospital setting

Dengue

Rapidly spreading climate-sensitive disease with no specific treatment

We’re building a global partnership with dengue-endemic countries to develop a first treatment

Father walking in rural village with a cane and holding his son's hand

Filaria: river blindness

Lead to unbearable itching, disfiguring skin lesions, and even blindness

We’re working to develop a safe, effective, and affordable drug for the prevention and treatment of this debilitating disease

Young man standing in the street

Hepatitis C

Millions are left without treatment even though effective drugs exist

We’ve delivered a treatment as simple, safe, and effective as the best drugs available today – at a fraction of the cost 

Woman standing in front of her door house in a rural village in Sudan

Mycetoma

Often ends in amputation​, after people get infected from stepping on a thorn

We conducted the world’s first trial for an alternative to current treatments, which are toxic and difficult to administer

Mother holding her baby in her arms smiling

Paediatric HIV

Without treatment, half of children die before their second birthday

We’ve developed a strawberry-flavoured treatment to meet the needs of children long neglected by the global HIV response

Healthcare workers in a hospital

Pandemic Preparedness

The COVID-19 pandemic intensified global health inequalities

We’re bringing together partners and accelerating research to prepare for future viral pandemics in low-resource settings

Doctor diagnosing a man in a village with his hands on the man's neck

Sleeping sickness

Transmitted by the bite of a tsetse fly and causes severe neurological disorders

We delivered a revolutionary new drug to replace toxic treatments, and have ongoing trials to eliminate this disease

Girl looking over a fence

Visceral leishmaniasis

Is one of the world’s biggest parasitic killers, spread by the bites of sandflies

We’re working to develop a new generation of treatments to replace drugs that are painful, ineffective, and cause side effects

Chagas disease

Cryptococcal meningitis

Cutaneous leishmaniasis

Dengue

Filaria: river blindness

Hepatitis C

Mycetoma

Paediatric HIV

Pandemic Preparedness

Sleeping sickness

Visceral leishmaniasis

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