Chagas disease
In search of shorter, better treatments to stop a silent killer
We developed the first-ever treatment for children and established a research network of over 400 people representing 150 organizations on three continents to advance new treatments and improve patients’ lives. Our teams are now working to develop safer, more effective medicines and to break down barriers to testing and treatment.
There are only two drugs – both discovered half a century ago – available to treat Chagas disease, a potentially fatal parasitic illness transmitted by insects known as ‘kissing bugs’, that hide in cracks in walls and furniture. If not treated, Chagas disease can cause irreversible, life-threatening damage to the heart and other vital organs.
Endemic in Latin America and the southern US, it is also present in Europe, Japan, and Australia. The current treatment for the disease is effective but lasts eight weeks and sometimes has serious side effects.
‘We need to raise the population’s awareness about Chagas disease and eliminate beliefs and fears about treatment.’
What we have achieved
We have been active in Chagas research and development, treatment access, and advocacy for more than two decades. Together with our research partners, we helped create the Chagas Clinical Research Platform, a network of over 400 members representing 150 organizations across three continents, to utilize and strengthen R&D capacity in endemic countries.
First-ever treatment for children. With our partners, we developed and registered the first-ever formulations of benznidazole for treating infants and children with Chagas disease.
What we are doing for people living with Chagas disease
Our goal is to make treatment safer, simpler, and more effective. We are also working to improve access to testing and treatment, and develop better tests of cure for treatment monitoring.
Boosting access to diagnosis and treatment. Fewer than 10% of people with Chagas know they have the disease. We are working with Ministries of Health and a broad range of partners in Colombia, Brazil, Guatemala, and elsewhere to expand people’s access to diagnosis and treatment.
Proving treatment efficacy remains a challenge. The lack of a reliable test to monitor treatment efficacy is a major hurdle for developing new drugs for Chagas disease. We are supporting research and raising awareness of the need for ‘biomarkers’ that can be measured with quick and accurate tests.
Chagas disease news & resources
Making medical history for neglected patients
We develop urgently needed treatments for neglected patients and ensure they’re affordable, available, and adapted to the communities who need them
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