New candidates are needed to fill the pipeline for Chagas disease treatments. The UW series is a novel series of T. cruzi inhibitors based on a 2-aryl benzothiazole scaffold identified by Fred Buckner and his group at University of Washington. The lead compound, 45DAP076, is one of the very few compounds that provides single compound cure in an in vivo model of chronic Chagas disease up to 180 days after infection. A set of additional compounds based on the closely related scaffold are being prepared to further improve the efficacy and remove concerns associated with the lead compound.

Project updates

2021

Compound optimization of the UW-series with a focus on optimizing the drug property profile of series compounds progressed significantly in 2021. A second generation of compounds has been confirmed to provide single-compound cure in an in vivo model of chronic Chagas disease up to 180 days after infection. 

2020

Efforts continued but were heavily impacted by the COVID-19 pandemic.