Dengue Alliance
Dengue Alliance
Developing affordable and accessible treatments for dengue through partnerships with institutions in the most affected countries
Founded: 2022
A global partnership led by institutions from dengue-endemic countries, the Dengue Alliance is advancing urgently needed pre-clinical research, testing the efficacy of repurposed drug candidates, and implementing clinical trials of the most promising potential dengue treatments. Alliance members also coordinate efforts to help overcome knowledge gaps, expedite clinical research and regulatory review, address unmet needs in diagnostics, mobilize resources, and share research knowledge openly.
Dengue, a climate-sensitive neglected tropical disease, is one of the top ten threats to global public health worldwide. Despite an estimated 390 million infections each year in more than 100 countries, there is no specific treatment available. More than 70% of the disease burden is estimated to be in Asia, with rapidly growing incidence in other parts of the world – in particular the Americas.
Alliance updates
2023
- 3 laboratories upgraded (Senegal, Democratic Republic of the Congo, and Ghana).
- 13 people trained for clinical trials.
- Held two expert meetings to discuss clinical trial design for dengue.
- Participated in ASTMH and ECTMIH conferences.
- Published two journal articles on the Alliance’s ongoing dengue seroprevalence study.
- Progressed pre-clinical profiling of existing direct-acting antiviral compounds and host-directed therapies.
2022
- Held an expert consultation on laboratory testing in dengue seroprevalence studies with 26 participants representing 12 countries and 10 institutions.
- Completed pre-clinical profiling of three direct-acting antiviral compounds for their potential to inhibit the dengue virus.
- Prepared and submitted protocols for a dengue seroprevalence study.
- Concluded collaboration agreements with six research institutions in the Dengue Alliance.






News & resources
- 4 February 2025 – Hyundai Bio (HDB) and DNDi sign MOU for joint development of Xafty-based dengue treatment
- 7 November 2024 – Treating a feverish planet: The Dengue Alliance
- 14 June 2024 – Identificaron un compuesto que puede actuar contra el dengue y Zika, Infobae
- 24 April 2024 – When dengue affects rich countries, will we take it more seriously?, BFM
- 15 April 2024 – Why we need a Global Dengue Alliance, The Global Sentinel
- 13 April 2024 – Cuáles son las terapias específicas contra el virus del dengue que investiga la ciencia, Infobae
- 1 April 2024 – Aligning to combat dengue, The Star
- 6 September 2023 – Consider This: Public health – tackling dengue through collaboration, Astro AWANI
- 4 September 2023 – Dengue Alliance sets goal to deliver treatment within 5 years, The Pioneer
- 1 September 2023 – A global dengue coalition to deliver treatment within 5 years: Lancet comment, Press Trust of India
- 31 August 2023 – Treatments for dengue: a Global Dengue Alliance to address unmet needs, The Lancet Global Health
- 15 April 2023 – El fuerte avance del dengue en los últimos 50 años: cuáles son las estrategias científicas en América para frenarlo, Infobae
- 20 February 2023 – First in-person Dengue Alliance meeting brings together experts from dengue-endemic countries to develop treatments for a growing viral threat
- 29 April 2022 – Ministry of Health, Malaysia and Drugs for Neglected Diseases initiative combine forces to lead the battle against dengue
- 26 January 2022 – New global research partnership to find treatment for dengue – DNDi
Stay connected
Get our latest news, personal stories, research articles, and job opportunities.