Our not-for-profit drug discovery and development experience, as well as our collaborative, open-science model, can help prepare for future pandemics.
We are participating in several ambitious drug discovery projects focused on coronaviruses, flaviviruses, and enteroviruses to identify new drug candidates for the treatment of diseases of pandemic potential, such as MERS, dengue, Zika fever, and yellow fever.
Our approach is focused on ensuring the needs of vulnerable communities are not forgotten. The COVID-19 pandemic threw longstanding global health inequalities into stark relief. Wealthy countries had access to advanced vaccines and therapeutics as soon as they were approved while many low- and middle-income countries were left grasping for basic supplies. It is more important than ever to prepare for future viral pandemics by strengthening global health R&D systems and ensuring the principles of access, affordability, and equity are embedded in the R&D process itself.
What we are doing for pandemic preparedness
We are using our experience in non-profit drug development and our partnerships with medical research institutions worldwide to prepare for future viral pandemics in low- and middle-income countries.
Using AI to identify antivirals for future pandemics. Funded by the NIH, the ASAP project uses cutting-edge technology to accelerate open science drug discovery to deliver novel oral antivirals against a wide range of viruses of pandemic potential, included currently neglected ones. The project aims at equitable and affordable global access.
Together with partners in the AI-driven Structure-enabled Antiviral Platform (ASAP), AViDD Center, funded by the NIH, we’re working to progress the development of back-up compounds to the frontrunner SARS-CoV-2 main protease (Mpro) inhibitor named DNDI-6510, initially identified by the Covid Moonshot initiative.
Open science against the world’s most dangerous viruses. This partnership between DNDi and the German Center for Infection Research (DZIF) is screening a selection of nucleoside drugs for the broadest possible antiviral activity against families of viruses presenting the greatest epidemic and pandemic threats.
Open-science search for a globally accessible COVID-19 antiviral. COVID Moonshot is a worldwide, virtual, open science collaboration of more than 150 scientists who partnered to identify new molecules that could block SARS-CoV-2 infection – with the aim to deliver an affordable and accessible COVID-19 treatment.
What we have achieved
We engaged in collaborative drug discovery partnerships to develop affordable, effective new COVID-19 treatments. We also mobilized partners around the world, particularly in low- and middle-income countries, to build clinical trials networks, share knowledge, and conduct research with a particular focus on finding solutions for low-resource settings.
Preparing clinical infrastructure for the next pandemic. Along with partners, DNDi co-founded PANTHER to prepare and respond rapidly to pandemics on the African continent by providing the human, technical, scientific, and administrative infrastructure through a network of experienced African research centres.
A network for research in low- and middle-income countries. In 2020, DNDi co-launched CERCLE, a coalition of 900 researchers & research institutions aiming to accelerate research on infectious diseases of pandemic potential by ensuring the participation – and meeting the specific needs of low-resource settings.
A multi-country trials focusing on mild and moderate cases of COVID-19. Conducted across 29 clinical trial sites in 13 African countries and Brazil by 27 medical research organizations, the ANTICOV study tested treatments that could reduce the risk of hospitalization.
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