We are using our not-for-profit drug development experience and partnerships to contribute to the COVID-19 response and prepare for future pandemics, notably in Africa and Latin America.
Since the start of the COVID-19 pandemic, we have coordinated a large COVID-19 clinical trial in 13 African countries, we have launched a new pan-African clinical research platform whose objective is to lay the groundwork for clinical trials before outbreaks occur, and we are participating in several ambitious drug discovery projects to identify medicine candidates for the treatment of viruses of pandemic potential.
The COVID-19 pandemic threw longstanding global health inequalities into stark relief. Wealthy countries had access to advanced vaccines and therapeutics as soon as they were approved while many low- and middle-income countries were left grasping for basic supplies. As COVID-19 shifts away from being the grave threat to lives and livelihoods it was at the beginning of the crisis, it is more important than ever to prepare for future viral pandemics by strengthening global health R&D systems and ensuring the principles of access, affordability, and equity are embedded in the R&D process itself.
‘ANTICOV is a clear demonstration of the capacity in Africa to conduct robust and extremely complex studies’
What we are doing for pandemic preparedness
We are using our experience in non-profit drug development and our partnerships with medical research institutions worldwide to prepare for future viral pandemics in low- and middle-income countries.
Open-science search for a globally accessible COVID-19 antiviral. COVID Moonshot is a worldwide, virtual, open science collaboration of more than 150 scientists who partnered to identify new molecules that could block SARS-CoV-2 infection – with the aim to deliver an affordable and accessible COVID-19 treatment.
Using AI to identify antivirals for future pandemics. Funded by the NIH, the ASAP project uses cutting-edge technology to accelerate open science drug discovery to deliver novel oral antivirals against a wide range of viruses of pandemic potential, included currently neglected ones. The project aims at equitable and affordable global access.
Open science against the world’s most dangerous viruses. This partnership between DNDi and the German Center for Infection Research (DZIF) is screening a selection of nucleoside drugs for the broadest possible antiviral activity against families of viruses presenting the greatest epidemic and pandemic threats.
Preparing clinical infrastructure for the next pandemic. PANTHER aims to prepare and respond rapidly to pandemics on the African continent by providing the human, technical, scientific, and administrative infrastructure on emerging infectious diseases through a network of experienced African research centres.
A network for research in low- and middle-income countries. DNDi is hosting CERCLE, a coalition of 900 researchers & research institutions aiming to accelerate research on infectious diseases of pandemic potential by ensuring the participation – and meeting the specific needs of low-resource settings.
What we have achieved
We engaged in collaborative drug discovery partnerships to develop affordable, effective new COVID-19 treatments. We also mobilized partners around the world, particularly in low- and middle-income countries, to build clinical trials networks, share knowledge, and conduct research with a particular focus on finding solutions for low-resource settings.
A multi-country trials focusing on mild and moderate cases of COVID-19. Conducted across 29 clinical trial sites in 13 African countries and Brazil by 27 medical research organizations, the ANTICOV study tested treatments that could reduce the risk of hospitalization.
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