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  • DNDi_Logo_No-Tagline_Full Colour
  • Our work
    • Diseases
      • Sleeping sickness
      • Visceral leishmaniasis
      • Cutaneous leishmaniasis
      • Chagas disease
      • Filaria: river blindness
      • Mycetoma
      • Paediatric HIV
      • Cryptococcal meningitis
      • Hepatitis C
      • Dengue
      • Pandemic preparedness
      • Antimicrobial resistance
    • Research & development
      • R&D portfolio & list of projects
      • Drug discovery
      • Translational research
      • Clinical trials
      • Registration & access
      • Treatments delivered
    • Advocacy
      • Open and collaborative R&D
      • Transparency of R&D costs
      • Pro-access policies and IP
      • Children’s health
      • Gender equity
      • Climate change
      • AI and new technologies
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    • Partnerships
      • Our partners
      • Partnering with us
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      • Chagas Platform
      • Dengue Alliance
      • HAT Platform
      • LEAP Platform
      • redeLEISH Network
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      • DNDi DRC
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Home

Research and development

We put neglected communities at the heart of drug R&D

Home

Research and development

We put neglected communities at the heart of drug R&D

Advancing medical innovation from laboratory bench to patient bedside

Our teams have been working since 2003 to address gaps in the traditional biomedical R&D system that lead to serious unmet medical needs for neglected patients. Acting as a ‘conductor of a virtual orchestra’, DNDi collaborates with research partners around the world at all stages of the R&D process. Together, we’ve discovered, developed, and delivered new treatments that reduce illness, suffering, and death from some of the world’s most neglected diseases.

Drug discovery

Translational research

Clinical trials

Registration and access

Project portfolio

We are working on more than 40 research and treatment access projects, including 21 focused on identifying or developing new chemical entities.

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Treatments delivered

We have delivered thirteen new treatments for six deadly diseases, saving millions of lives.

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Scientific articles

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Scientific articles
30 Sep 2025

New regimens of benznidazole for the treatment of chronic Chagas disease in adult participants in indeterminate form or with mild cardiac progression (NuestroBen study): protocol for a phase III randomised, multicentre non-inferiority clinical trial

BMJ Open
Scientific articles
29 Sep 2025

Performance evaluation of rapid diagnostic tests for Chagas disease in Jutiapa, Guatemala

Journal of the Brazilian Society of Tropical Medicine
Scientific articles
22 Sep 2025

Mass balance, pharmacokinetics, metabolism, and excretion of radiolabeled acoziborole, a potential novel treatment for human African trypanosomiasis, following single microtracer oral dose to humans

Antimicrobial Agents and Chemotherapy
Scientific articles
8 Sep 2025

Quantifying anti-trypanosomal treatment effects in chronic indeterminate Chagas disease: a secondary analysis of individual patient data from two proof-of-concept trials

The Lancet Microbe
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Target product profiles (TPPs)

TPPs serve to ensure that all products are designed from the start for the people and places that need them by describing the ideal specifications needed for a treatment.

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Events

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4-6 November 2025

Antwerp, Belgium & online

65th ITM Colloquium

2-5 November 2025

João Pessoa, Brazil

MedTrop 2025

2-5 November 2025

Lyon, France

One Sustainable Health for All Forum

22-25 October 2025

Durban, South Africa

CPHIA 2025

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International non-profit developing safe, effective, and affordable treatments for the most neglected patients.

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