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  • DNDi_Logo_No-Tagline_Full Colour
  • Our work
    • Diseases
      • Sleeping sickness
      • Visceral leishmaniasis
      • Cutaneous leishmaniasis
      • Chagas disease
      • Parasitic worms
      • Mycetoma
      • Dengue
      • Paediatric HIV
      • Cryptococcal meningitis
      • Hepatitis C
      • Pandemic preparedness
      • Antimicrobial resistance
    • Research & development
      • R&D portfolio & list of projects
      • Drug discovery
      • Translational research
      • Clinical trials
      • Registration & access
      • Treatments delivered
    • Advocacy
      • Open and collaborative R&D
      • Transparency of R&D costs
      • Pro-access policies and IP
      • Children’s health
      • Gender equity
      • Climate change
      • AI and new technologies
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    • Partnerships
      • Our partners
      • Partnering with us
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      • Chagas Platform
      • Dengue Alliance
      • HAT Platform
      • LEAP Platform
      • redeLEISH Network
    • DNDi worldwide
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      • DNDi Eastern Africa
      • DNDi Japan
      • DNDi Latin America
      • DNDi North America
      • DNDi South Asia
      • DNDi South-East Asia
      • DNDi West and Central Africa
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Home

Research and development

We put neglected communities at the heart of drug R&D

Home

Research and development

We put neglected communities at the heart of drug R&D

Advancing medical innovation from laboratory bench to patient bedside

Our teams have been working since 2003 to address gaps in the traditional biomedical R&D system that lead to serious unmet medical needs for neglected patients. Acting as a ‘conductor of a virtual orchestra’, DNDi collaborates with research partners around the world at all stages of the R&D process. Together, we’ve discovered, developed, and delivered new treatments that reduce illness, suffering, and death from some of the world’s most neglected diseases.

Drug discovery

Translational research

Clinical trials

Registration and access

Project portfolio

We are working on more than 40 research and treatment access projects, including 21 focused on identifying or developing new chemical entities.

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Treatments delivered

We have delivered fourteen new treatments for six deadly diseases, saving millions of lives.

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Scientific articles

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Scientific articles
27 Feb 2026

Design and analysis of randomized clinical trials for onchocerciasis, loiasis and mansonellosis: A systematic review

PLOS Neglected Tropical Diseases
Scientific articles
18 Feb 2026

An MRC-5 cell based high-throughput, high-content imaging assay to identify hits against Trypanosoma cruzi intracellular parasites

SLAS Discovery
Scientific articles
27 Feb 2026

Evaluation of drug–drug interaction potential between the oral antibiotic zoliflodacin and the CYP3A4 inhibitor itraconazole: A phase 1 study in healthy participants

Clinical and Translational Science
Scientific articles
26 Feb 2026

A Computational Community Blind Challenge on Pan-Coronavirus Drug Discovery Data

Journal of Chemical Information and Modeling
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Target product profiles (TPPs)

TPPs serve to ensure that all products are designed from the start for the people and places that need them by describing the ideal specifications needed for a treatment.

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Events

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20 May 2026

London, UK & Online

MSF Scientific Days

28-30 April 2026

Bangkok, Thailand

World Hepatitis Summit 2026

27 April – 1 May 2026

Prague, Czech Republic

ICAR 2026

27-29 April 2026

Nairobi, Kenya

World Health Summit Regional Meeting 2026

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International non-profit developing safe, effective, and affordable treatments for the most neglected patients.

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