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Home > Press Releases Translations

에스티팜, 국제 비영리 신약개발재단(DNDi)과 공정기술개발 협약 체결

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에스티팜, 국제 비영리 신약개발재단(DNDi)과 공정기술개발 협약 체결

Lab activities
SEOUL / GENEVA — 27 Jul 2022
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  • 한국어
    • English
    • 한국어
  • 에스티팜의 CFT 신기술을 적용한 공정 최적화로 중저소득국을 위한 저렴한 치료제 급 계획
  • 글로벌 비영리 보건의료 사업에 참여함으로써 사회적 책임을 다하는 경영철학의 실천

에스티팜(대표이사 사장 김경진)은 스위스 소재 국제 비영리 소외질환신약개발재단(DNDi, Drugs for Neglected Disease Initiative)과 내장 리슈만편모충증(VL) 후보물질의 상업화 전 공정 최적화를 위한 협약을 체결했다고 X일 밝혔다.

2003년에 설립된 DNDi는 국경없는의사회(MSF), 세계보건기구(WHO) 및 5개의 주요 국제 연구기관이 공동으로 설립한 비영리 단체로, 상업성이 낮아 글로벌제약사들이 개발을 꺼려하는 소외질병 치료제를 개발하고 있다. 그러나 현재 제조 공정으로는 생산비가 높아 중저소득국 환자들이 치료비용을 감당할 수 없으므로 상업화 전에 공정기술 최적화로 비용 절감이 필요하다. DNDi는 한국의 국제보건 분야 연구비 지원기관인 재단법인 글로벌헬스기술연구기금(라이트펀드)의 2022년도 연구비 지원대상으로 선정되어 에스티팜과 이번 협약에 따른 공정 최적화 연구를 추진하게 되었다.

이번 협약을 통해 에스티팜은 현재 글로벌 임상 1상이 진행 중인 해당 신약의 공정 최적화를 맡아 공정 횟수를 줄이고 대체 공정을 적용하는 등 보다 저렴하게 생산할 수 있는 공정기술을 개발하게 된다. 또한 에스티팜의 혁신 기술인 환경 친화적 CFT(Continuous Flow Technology, 연속 흐름 생산) 기술을 적용하여 수율 향상과 순도 개선 및 생산 폐기물을 최소화할 예정이다. 공정 최적화에 성공하면 양사는 추가 공정기술을 개발하고 임상 3상을 위한 시료 생산을 추진할 계획이다.

모래파리에게 물려 감염되는 내장 리슈만편모충증은 환자의 간과 비장 등 내장을 공격하여 급성 빈혈과 백혈병을 유발하는 등 조기에 치료하지 않으면 사망에까지 이르는 치명적인 기생충 감염 질환이다. 동아프리카, 인도 및 라틴아메리카에서 약 6억 명이 내장 리슈만편모충증 감염 위험에 노출되어 있으며 매년 5 ~ 9만 명이 감염되지만 기존 약물은 안전성과 비용 면에서 단점이 있다.

에스티팜의 최준영 합성연구소장은 “에스티팜의 혁신적인 기술이 치료제를 구할 수 없는 저소득국가의 빈곤층 환자들 특히 어린이들에게 희망을 줄 수 있어, DNDi와의 이번 협약에 대해 매우 기쁘게 생각한다”고 말했다.

DNDi의 제약 개발 이사인 Dr. Stephen Robinson은 “우리는 전 세계적으로 위험에 처한 수백만 명의 사람들에게 저렴하게 공급할 수 있는 미래 치료제를 만들기 위해 에스티팜의 첨단기술과 화학 공정 전문 역량을 적용하여 제조공정을 최적화할 것이며 이 파트너십을 한국에서 시작하게 되어 매우 기쁘다”고 소감을 밝혔다.

한편 에스티팜은 SMB(Simulated Moving Bed, 모사 이동층 분리 정제)와 CFT(Continuous Flow Technology, 연속 흐름 생산)두 개의 혁신기술을 주력 사업분야에 적용해 생산성을 높여 원가를 절감하고 유기용매의 사용을 최소화해 친환경 공정을 구현하고 있다.

Media contact

DNDi
Frédéric Ojardias
fojardias@dndi.org
+41 79 431 6216

ST Pharm
Inhye Choi (Seoul)
choih1223@stpharm.co.kr
+82 2 527 6317

Photo credit: Vinicius Berger – DNDi

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