Extreme heat, drought, floods, and shifting rainfall patterns can increase infectious disease risks while simultaneously disrupting health services, supply chains, and the stability, effectiveness, and delivery of essential health products. This joint policy brief from CEPI, DNDi, Gavi, IVCC, MMV, and Unitaid argues that tackling climate-sensitive infectious diseases must become a core climate adaptation priority. It outlines practical actions to strengthen surveillance and preparedness, invest in new, climate-resilient health tools, build resilient and equitable innovation and delivery systems, and unlock climate finance for infectious disease prevention and response.