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Home > Our people > Leadership > R&D
Ivan Scandale

Ivan Scandale

Discovery Leader, DNDi

Ivan Scandale joined DNDi in April 2008 as a project coordinator. He has been responsible for projects ranging from early screening to late preclinical stage. In particular, he contributed to the discovery and development of acoziborole for sleeping sickness. He has also established a filarial discovery programme which provided a small pipeline of clinical candidates.

Prior to joining DNDi, Ivan has worked as an R&D scientist at TRB Chemedica, a Swiss medium-size pharmaceutical company active in ophthalmology, rheumatology, and neurology.

Ivan has a background in chemical engineering from the Swiss Federal Institute of Technology (EPFL) and in industrial chemistry from the University of Genoa.

Featured news & publications

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  • Pharmacokinetic-pharmacodynamic modeling of benznidazole and its antitrypanosomal activity in a murine model of chronic Chagas disease
  • A guide for the generation of repositories of clinical samples for research on Chagas disease
  • Further preclinical characterization of molnupiravir against SARS-CoV-2: Antiviral activity determinants and viral genome alteration patterns
  • Onchocerciasis drug discovery: In vitro evaluation of FDA-approved drugs against onchocerca gutturosa in Gambia
  • Generation and evaluation of protease inhibitor-resistant SARS-CoV-2 strains
  • Bioluminescence imaging reveals enhanced SARS-CoV-2 clearance in mice with combinatorial regimens
  • Preclinical data do not support the use of amiodarone or dronedarone as antiparasitic drugs for Chagas disease at the approved human dosing regimen
  • State-of-the-art in the drug discovery pathway for Chagas disease: A framework for drug development and target validation
  • Comparison of the macrofilaricidal efficacy of oxfendazole and its isomers against the rodent filaria Litomosoides sigmodontis
  • Comparing in vivo bioluminescence imaging and the Multi-Cruzi immunoassay platform to develop improved Chagas disease diagnostic procedures and biomarkers for monitoring parasitological cure

Featured events

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  • ASTMH 2022
  • PAGE 2022 Meeting
  • 3rd World Conference on Pharmacometrics (WCoP)
  • Population Approach Group Europe Meeting 2021
  • ASTMH 2020

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