redeLEISH network
redeLEISH network

Promoting research for improved cutaneous leishmaniasis treatments by increasing collaboration and maximizing resources in Latin America
Founded: 2014
The redeLEISH Network brings together leishmaniasis experts in Latin America to leverage and strengthen local expertise with the aim of closing gaps in the treatment and management of cutaneous leishmaniasis in the region.
With 204 members from 91 institutions across 28 countries, the Network promotes information sharing on cutaneous leishmaniasis treatment, diagnosis, and clinical trial design. It also enables the exchange of technical and scientific knowledge among participants and contributes to the implementation of strategic policies and research priorities. By mapping potential research centres and implementing Good Clinical Practice training, redeLEISH also strengthens institutional capacity for clinical research.
A web forum facilitates technical exchange to support the implementation of clinical trials in the region. Created in 2015, this virtual tool helps to integrate members, promote dialogue, provide updates on clinical trial progress and implementation, share documents and publications, and generate discussions on R&D and access challenges specific to cutaneous leishmaniasis in Latin America.
Previous InfoLEISH newsletters
Newsletter No. 7, September 2023
English Español Português
Newsletter No. 6, July 2022
English Español Português
Newsletter No. 5, October 2021
English Español Português
Newsletter No. 4, July 2019
English Español Português
Newsletter No. 3, June 2018
English Español Português
redeLEISH Manifesto
redeLEISH released a manifesto during the WorldLeish 7 conference in August 2022 calling on the scientific community and health authorities to prioritize the need to develop simple diagnostic techniques for cutaneous leishmaniasis.
Platform updates
2023
- 6 active clinical sites in Brazil, Panama, Peru, and Bolivia.
- 2 ongoing clinical trials led by redeLEISH member institutions.
- 8 publications and 7 events shared via the redeLEISH web forum.
- Obtained further support for the redeLEISH manifesto calling for urgent action to develop more effective, user-friendly, point-of-care diagnostic tools.
2022
- 8 active clinical sites in Brazil, Panama, Peru, and Bolivia.
- 18 people trained for clinical trials.
- 2 ongoing clinical trials led by redeLEISH member institutions.
- Participated in the 7th World Congress on Leishmaniasis (WorldLeish7) held in Cartagena, Colombia in August 2022.
- Developed redeLEISH manifesto calling for urgent innovation for user-friendly, point-of-care rapid diagnostic tools for Chagas disease, obtaining signatures from 36 representatives from 18 institutions, with a further 651 online signatures obtained via social networks and participation in regional scientific conferences following the launch of the manifesto at WorldLeish7.
- Participated in MedTrop Congress in Brazil in November 2022, and XVII Parasitology and Tropical Medicine Congress held in Colombia in November and December 2022.
- Presented the results of a data-sharing project to collect information on the efficacy of routine CL treatment for children 10 years old and younger, implemented with the support of WHO-TDR, the Special Programme for Research and Training in Tropical Diseases, at WorldLeish7.
2021
- 7 active clinical sites in Brazil, Panama, and Peru.
- 32 people trained for clinical trials.
- 2 ongoing clinical trials led by redeLEISH member institutions.
- Completed a data-sharing project to collect information on the efficacy of routine CL treatment for children 10 years old and younger, implemented with the support of WHO-TDR, the Special Programme for Research and Training in Tropical Diseases, to provide evidence and recommendations for national leishmaniasis programmes. 10 institutions from 4 countries (Brazil, Colombia, Bolivia, and Peru) participated in the project, and the results were shared with PAHO.
- Conducted a systematic review of therapeutic response and relapse rates in patients treated for CL to obtain consensus on timelines for efficacy assessments in clinical trials.
- Held 5 virtual focus groups with experts and key stakeholders to understand perspectives on the usefulness, benefits, barriers, and acceptability of thermotherapy for CL treatment.
2020
- 8 active clinical sites.
- 1 clinical trial managed by member institutions.
- Completed data collection on the efficacy of routine CL treatment for children 10 years old and younger, implemented with the support of WHO-TDR, the Special Programme for Research and Training in Tropical Diseases, to provide evidence and recommendations for national leishmaniasis programmes. 10 institutions from 4 countries (Brazil, Colombia, Bolivia, and Peru) participated in the project.
- Although physical meetings, trainings, and clinical trials were hampered by the COVID-19 pandemic, a total of 19 scientific publications, 4 events, 2 courses, and 5 discussions were shared on the redeLEISH web forum.
2019
- Data-sharing project, with support of WHO-TDR, to collect information on routine CL treatment efficacy in children up to 10 years of age and elderly people in order to provide evidence and make recommendations to the national leishmaniasis programmes of Brazil, Colombia, Bolivia, and Peru for case management
- Facilitated the development of consensus among investigators to reduce the follow-up time to assess treatment efficacy for CL patients included in clinical trials, from 180 days to 90 days
- Preparation of a Phase III CL clinical trial in five sites in Bolivia, Brazil, Panama, and Peru
- Collaborative project of four RedeLEISH sites in Brazil to conduct a clinical trial to assess efficacy and safety of a drug combination for mucosal leishmaniasis
2018
- 62 people trained in Good Clinical Practice at Fundação Oswaldo Cruz, in collaboration with DNDi, and 30 on leishmaniasis in a multicountry training.
- Conducted clinical trial to assess efficacy and safety of a drug combination for mucosal leishmaniasis
- Supported the creation of the first association of leishmaniasis patients in Brazil (ABRAPLEISH)
- Supported the third edition of the ‘Brazilian Patients Forum against Infectious and Neglected Diseases’ during the 54th Brazilian Congress of Tropical Medicine (MedTrop).
- With WHO/TDR, supported harmonization of criteria for cutaneous leishmaniasis clinical trials and conducted a systematic review to assess therapeutic response and relapse rates.
2017
- Launch of a manifesto, signed by 143 investigators and civil society representatives, for mucocutaneous leishmaniasis to raise the awareness of the scientific community and policy makers of the urgent need for more research for this very neglected form of leishmaniasis.
- Co-organization of the ‘Brazilian Patients Forum against Infectious and Neglected Diseases’ during the 53rd Brazilian Congress of Tropical Medicine (MedTrop).
- In coordination with TDR/WHO, supported efforts on the harmonization of criteria for clinical trials in cutaneous leishmaniasis and conducted a systematic review to assess therapeutic response and relapse rates.
2016
- Completion of a collaborative research project of species identification conducted in Pará, Mato Grosso, and Acre (Brazil), and preliminary results presented during annual meeting.
- INFOLEISH, the network’s first newsletter was launched in May
2015
- Originally created as a Brazilian network of investigators, in 2015, redeLEISH was extended to include reference centres and experts from other Latin American countries.
- The second meeting was held in Medellin, Colombia, with the collaboration of PECET (Program for the Study and Control of Tropical Diseases/ University of Antioquia), and Ruta N Medellin. This meeting had more than 65 representatives from 35 institutions, among them 17 reference centers from 8 countries (Brazil, Colombia, Peru, Panama, Guatemala, Venezuela, Bolivia and Mexico), representatives of PAHO, TDR/WHO, FIOCRUZ, and of the Colombian and Brazilian Ministries of Health to identify the capacity of clinical research in Latin America and to consolidate the framework of collaborative projects. Furthermore, the agenda included a discussion towards the target product profile of a rapid diagnostic test for CL.
- A Webforum was created, to act as a virtual platform that could serve as a real space to share experiences in leishmaniasis.
- Centro Dermatológico Federico Lleras Acosta, Colombia
- Centro Internacional de Entrenamiento e Investigaciones Medicas (CIDEIM), Colombia
- Centro de Pesquisa Gonçalo Moniz-Fiocruz BA, Brazil
- Department of Parasitology, Public Health Training Program – U.S. Naval Medical Research Unit No. 6, Peru
- FIND, the global alliance for diagnostics, Switzerland
- FUNDERMA – Fundación Nacional de Dermatología, Bolivia
- Fundação de Medicina Tropical Heitor Vieira Dourado, Brazil
- Hospital Universitário Júlio Müller, Universidade Federal de Mato Grosso (UFMT), Brazil
- Instituto Colombiano de Medicina Tropical, Colombia
- Instituto Conmemorativo Gorgas de Estudios de la Salud, Panama
- Instituto Medico la Floresta, Venezuela
- Instituto Nacional de Infectologia Evandro Chagas (INI) – Fiocruz, Brazil
- Instituto Nacional de Infectologia – Fiocruz RJ, Brazil
- Instituto Nacional de Pesquisa da Amazônia (INPA), Brazil
- Instituto René Rachou (IRR) – Fiocruz Minas, Brazil
- Instituto de Salud Carlos III, Spain
- Lafepe Laboratório Farmacêutico do Estado de Pernambuco S/A, Brazil
- Ministry of Health Colombia, Colombia
- Ministério da Saúde Brasil, Brazil
- National Institute of Health Colombia, Colombia
- PECET – Programa de Estudios y Control de Enfermedades Tropicales, Colombia
- Pan American Health Organization (PAHO)
- Plataforma de Pesquisa Clínica – Fiocruz RJ, Brazil
- Secretaria Municipal de Saúde Unidade Referência em Atenção Primária Drª Claudia Vitorino, Brazil
- Universidad Mayor de San Simon, Bolivia
- Universidad Nacional Autónoma de México (UNAM), Mexico
- Universidad Peruana Cayetano Heredia, Peru
- Universidad del Valle, Guatemala
- Universidade Federal da Bahia (UFBA), Brazil
- Universidade Federal de Santa Catarina (UFSC), Brazil
- Universidade Federal do Ceará, Brazil
- Universidade Federal do Pará (UFPA), Brazil
- Universidade Federal do Piauí (UFPI), Brazil
- Universidade Federal do Rio de Janeiro (UFRJ), Brazil
- Universidade de Brasília – Núcleo de Medicina Tropical (UnB), Brazil
- Universidade de Pernambuco (UFPE), Brazil
- Universidade de São Paulo (USP), Brazil
- Universidade do Estado do Pará (UEPA), Brazil
- WHO-TDR, Special Programme for Research and Training in Tropical Diseases, Switzerland
- Centro de Pesquisa Gonçalo Moniz-Fiocruz BA
- ,Brazil
- Centro Dermatológico Federico Lleras Acosta
- ,Colombia
- Centro Internacional de Entrenamiento e Investigaciones Medicas (CIDEIM)
- ,Colombia
- Department of Parasitology, Public Health Training Program – U.S. Naval Medical Research Unit No. 6
- ,Peru
- FIND, the global alliance for diagnostics
- ,Switzerland
- Fundação de Medicina Tropical Heitor Vieira Dourado
- ,Brazil
- FUNDERMA – Fundación Nacional de Dermatología
- ,Bolivia
- Hospital Universitário Júlio Müller, Universidade Federal de Mato Grosso (UFMT)
- ,Brazil
- Instituto Colombiano de Medicina Tropical
- ,Colombia
- Instituto Conmemorativo Gorgas de Estudios de la Salud
- ,Panama
- Instituto de Salud Carlos III
- ,Spain
- Instituto Medico la Floresta
- ,Venezuela
- Instituto Nacional de Infectologia – Fiocruz RJ
- ,Brazil
- Instituto Nacional de Infectologia Evandro Chagas (INI) – Fiocruz
- ,Brazil
- Instituto Nacional de Pesquisa da Amazônia (INPA)
- ,Brazil
- Instituto René Rachou (IRR) – Fiocruz Minas
- ,Brazil
- Lafepe Laboratório Farmacêutico do Estado de Pernambuco S/A
- ,Brazil
- Ministério da Saúde Brasil
- ,Brazil
- Ministry of Health Colombia
- ,Colombia
- National Institute of Health Colombia
- ,Colombia
- Pan American Health Organization (PAHO)
- PECET – Programa de Estudios y Control de Enfermedades Tropicales
- ,Colombia
- Plataforma de Pesquisa Clínica – Fiocruz RJ
- ,Brazil
- Secretaria Municipal de Saúde Unidade Referência em Atenção Primária Drª Claudia Vitorino
- ,Brazil
- Universidad del Valle
- ,Guatemala
- Universidad Mayor de San Simon
- ,Bolivia
- Universidad Nacional Autónoma de México (UNAM)
- ,Mexico
- Universidad Peruana Cayetano Heredia
- ,Peru
- Universidade de Brasília – Núcleo de Medicina Tropical (UnB)
- ,Brazil
- Universidade de Pernambuco (UFPE)
- ,Brazil
- Universidade de São Paulo (USP)
- ,Brazil
- Universidade do Estado do Pará (UEPA)
- ,Brazil
- Universidade Federal da Bahia (UFBA)
- ,Brazil
- Universidade Federal de Santa Catarina (UFSC)
- ,Brazil
- Universidade Federal do Ceará
- ,Brazil
- Universidade Federal do Pará (UFPA)
- ,Brazil
- Universidade Federal do Piauí (UFPI)
- ,Brazil
- Universidade Federal do Rio de Janeiro (UFRJ)
- ,Brazil
- WHO-TDR, Special Programme for Research and Training in Tropical Diseases
- ,Switzerland
- FUNDERMA – Fundación Nacional de Dermatología, Bolivia
- Universidad Mayor de San Simon, Bolivia
- Centro de Pesquisa Gonçalo Moniz-Fiocruz BA, Brazil
- Fundação de Medicina Tropical Heitor Vieira Dourado, Brazil
- Instituto Nacional de Infectologia Evandro Chagas (INI) – Fiocruz, Brazil
- Instituto Nacional de Infectologia – Fiocruz RJ, Brazil
- Instituto Nacional de Pesquisa da Amazônia (INPA), Brazil
- Lafepe Laboratório Farmacêutico do Estado de Pernambuco S/A, Brazil
- Ministério da Saúde Brasil, Brazil
- Pan American Health Organization (PAHO),
- Plataforma de Pesquisa Clínica – Fiocruz RJ, Brazil
- Secretaria Municipal de Saúde Unidade Referência em Atenção Primária Drª Claudia Vitorino, Brazil
- Universidade de Brasília – Núcleo de Medicina Tropical (UnB), Brazil
- Universidade de Pernambuco (UFPE), Brazil
- Universidade de São Paulo (USP), Brazil
- Universidade do Estado do Pará (UEPA), Brazil
- Universidade Federal do Rio de Janeiro (UFRJ), Brazil
- Universidade Federal da Bahia (UFBA), Brazil
- Hospital Universitário Júlio Müller, Universidade Federal de Mato Grosso (UFMT), Brazil
- Universidade Federal de Santa Catarina (UFSC), Brazil
- Universidade Federal do Pará (UFPA), Brazil
- Universidade Federal do Piauí (UFPI), Brazil
- Centro Dermatológico Federico Lleras Acosta, Colombia
- Centro Internacional de Entrenamiento e Investigaciones Medicas (CIDEIM), Colombia
- Instituto Colombiano de Medicina Tropical, Colombia
- National Institute of Health Colombia, Colombia
- Ministry of Health Colombia, Colombia
- PECET – Programa de Estudios y Control de Enfermedades Tropicales, Colombia
- Universidad del Valle, Guatemala
- Universidad Nacional Autónoma de México (UNAM), Mexico
- Instituto Conmemorativo Gorgas de Estudios de la Salud, Panama
- Department of Parasitology, Public Health Training Program – U.S. Naval Medical Research Unit No. 6, Peru
- Universidad Peruana Cayetano Heredia, Peru
- FIND, the global alliance for diagnostics, Switzerland
- WHO-TDR, Special Programme for Research and Training in Tropical Diseases, Switzerland
- Instituto Medico la Floresta, Venezuela
- Instituto René Rachou (IRR) – Fiocruz Minas, Brazil
- Universidade Federal do Ceará, Brazil
- Instituto de Salud Carlos III, Spain
- Brazil - Ministry of Health Brazil
- Brazil - Fundação Oswaldo Cruz (Fiocruz)
- Brazil - Banco Nacional de Desenvolvimento Econômico e Social (BNDES)
- Colombia - Ruta-N / City of Medellin
- Germany - Federal Ministry for Economic Cooperation and Development (BMZ) through KfW
- Switzerland - Swiss Agency for Development and Cooperation (SDC)
- UK - UK International Development
- Médecins Sans Frontières International
- Other private foundations and individuals