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Home > Diseases
mycetoma icon

Mycetoma

Looking for alternatives to amputation

Home > Diseases
mycetoma icon

Mycetoma

Looking for alternatives to amputation

  • Overview
  • Facts
  • Projects & achievements
  • Target product profile

We ran the world’s first mycetoma clinical trial and are partnering with a virtual drug-discovery community to identify all-new treatments.

Mycetoma is a slow-growing infection that causes severe disabilities. Infection probably comes from the soil or animal dung and begins most often in the foot, after a cut allows the bacteria or fungus to enter. There is no effective cure for fungal mycetoma – amputation is often the only solution. Current treatments show moderate effectiveness, but due to the length of administration they are less suitable  and adapted for patients. They are also unaffordable and cause considerable side effects.

Icon interrogation point

Global burden is unknown

Icon parasite
of mycetoma cases worldwide are fungal
0 %
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‘I got mycetoma 19 years ago after I was pricked by a thorn. Even after numerous treatments, eight surgeries, and finally an amputation of my leg, I don’t think I am healed.’

Alsadik Mohammed Musa Omer, Khartoum, Sudan
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What we have achieved

We are bringing much needed attention to mycetoma to help end the neglect of people with the disease.

Advocating for one of the world’s most neglected diseases

Mycetoma was added to WHO’s official list of neglected tropical diseases in 2016. We also endorsed a ‘Call for Action’ to accelerate global efforts to address the needs of people living with mycetoma.

What we are doing for people living with mycetoma

Our aim is to develop a safe, effective, and affordable treatment that is suitable for use in rural areas.

Read more in our Annual Report
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Clinical trials

Fosravuconazole

The world’s first clinical trial for mycetoma treatment. Ran at the world’s only specialized centre for mycetoma, located in Khartoum, Sudan, this study tested Eisai’s fosravuconazole against the current standard treatment which is expensive, must be dosed twice a day for a year, and taken with food.

Drug discovery

MycetOS

Open-source drug discovery for mycetoma. DNDi is partnering with this virtual drug discovery community to find all-new treatments to end the neglect of fungal mycetoma – using a community-driven, fully transparent process that publishes data and results immediately in real time.

Registration & access

New mycetoma treatments

Ensuring access to safe, effective, affordable treatments. We are working to expand access to treatment and to better understand the burden of mycetoma in endemic areas.

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Mycetoma news & resources

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News
Press releases
Publications
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Scientific articles
21 Apr 2025

A balancing act: Navigating the advantages and challenges of pioneering mycetoma treatment in Sudan – A landmark trial by the Mycetoma Research Center

PLOS Neglected Tropical Diseases
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Publications
17 Mar 2025

MycetOS factsheet

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News
4 Mar 2025

2024 R&D programmes in review: Mycetoma

News
30 Jan 2025

Science and collaboration can end the neglect – World NTD Day 2025

See all news

Making medical history for neglected patients

We develop urgently needed treatments for neglected patients and ensure they’re affordable, available, and adapted to the communities who need them

Young boy sitting on a hospital bed being examined by a nurse

Chagas disease

Causes heart and vital organ damage, after people are bitten by blood-sucking bugs

We delivered the first-ever treatment for children; now we’re searching for new drug candidates and working to boost access to care

Patient medical examination

Cryptococcal meningitis

Without treatment, deadly for thousands of people with advanced HIV

We’re working to improve access to life-saving treatments and developing an easier-to-use formulation

Girl with skin lesions on her nose

Cutaneous leishmaniasis

Leaves disfiguring, life-long scars that lead to severe social stigma

We’re working to develop safer, shorter treatments for this disabling disease

Doctor with young patient in hospital setting

Dengue

Rapidly spreading climate-sensitive disease with no specific treatment

We’re building a global partnership with dengue-endemic countries to develop a first treatment

Father walking in rural village with a cane and holding his son's hand

Filaria: river blindness

Lead to unbearable itching, disfiguring skin lesions, and even blindness

We’re working to develop a safe, effective, and affordable drug for the prevention and treatment of this debilitating disease

Young man standing in the street

Hepatitis C

Millions are left without treatment even though effective drugs exist

We’ve delivered a treatment as simple, safe, and effective as the best drugs available today – at a fraction of the cost 

Woman standing in front of her door house in a rural village in Sudan

Mycetoma

Often ends in amputation​, after people get infected from stepping on a thorn

We conducted the world’s first trial for an alternative to current treatments, which are toxic and difficult to administer

Mother holding her baby in her arms smiling

Paediatric HIV

Without treatment, half of children die before their second birthday

We’ve developed a strawberry-flavoured treatment to meet the needs of children long neglected by the global HIV response

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Pandemic Preparedness

The COVID-19 pandemic intensified global health inequalities

We’re bringing together partners and accelerating research to prepare for future viral pandemics in low-resource settings

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Sleeping sickness

Transmitted by the bite of a tsetse fly and causes severe neurological disorders

We delivered a revolutionary new drug to replace toxic treatments, and have ongoing trials to eliminate this disease

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Visceral leishmaniasis

Is one of the world’s biggest parasitic killers, spread by the bites of sandflies

We’re working to develop a new generation of treatments to replace drugs that are painful, ineffective, and cause side effects

Chagas disease

Cryptococcal meningitis

Cutaneous leishmaniasis

Dengue

Filaria: river blindness

Hepatitis C

Mycetoma

Paediatric HIV

Pandemic Preparedness

Sleeping sickness

Visceral leishmaniasis

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