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Home > Scientific articles
Apr 2021
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The translational challenge in Chagas disease drug development

Memorias do Instituto Oswaldo Cruz

by Kratz JM, Gonçalves KR, Romera LMD, Moraes CB, Bittencourt-Cunha P, Schenkman S, Chatelain E, Sosa-Estani S. Memorias do Instituto Oswaldo Cruz 2021; 116: e200501. doi: 10.1590/0074-02760200501

Summary: There is an urgent need for safe, effective, and accessible new treatments for Chagas disease since the currently approved drugs have serious limitations. Drug development for Chagas disease has historically been hampered by the complexity of the disease, critical knowledge gaps, and lack of coordinated R&D efforts. This review covers some of the translational challenges associated with the progression of new chemical entities from preclinical to clinical phases of development and discusses how recent technological advances might allow the research community to answer key questions relevant to the disease and to overcome hurdles in R&D for Chagas disease.

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Translational research Chagas disease

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