by Oliveira RG, Cruz LR, Mollo MC, Dias LC, Kratz JM. Frontiers in Chemistry 2021;9:948. doi: 10.3389/fchem.2021.771143
Summary: In this article, the authors focus on drug discovery programs for Chagas disease led by scientists based in Latin America, the main endemic area. They review what has been published on the identification of new antiparasitic drugs to treat Chagas disease in the last decade, shining a spotlight on the origin, chemical diversity, level of characterization of hits, and strategies used for optimization of lead compounds. They identify strengths and weaknesses in these drug discovery campaigns and highlight the importance of multidisciplinary collaboration and knowledge sharing.