Explore whether existing approved treatment approaches for cutaneous leishmaniasis are more effective when used in combination
current phase of drug development
updated 1 Jun 2021
When administrated alone, the safety and efficacy profiles of current cutaneous leishmaniasis treatments (antimonials, miltefosine, and thermotherapy) are well established. For people with uncomplicated cutaneous leishmaniasis, where lesions are small in number and size and are not located on the face or on joints, thermotherapy – applying heat to the wound for a short duration – is the most practical and effective treatment option.
Using a combination of therapeutic approaches may improve efficacy rates, shorten treatment duration, and reduce the rate of adverse events. The Phase II study found that a combination of thermotherapy with a shorter course of oral miltefosine achieves significantly better results than thermotherapy alone. Next, a Phase III study will assess the combination treatment for non-inferiority against current recommended treatments.
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