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  • Our work
    • Diseases
      • Sleeping sickness
      • Visceral leishmaniasis
      • Cutaneous leishmaniasis
      • Chagas disease
      • Filaria: river blindness
      • Mycetoma
      • Paediatric HIV
      • Cryptococcal meningitis
      • Hepatitis C
      • Dengue
      • Pandemic preparedness
      • Antimicrobial resistance
    • Research & development
      • R&D portfolio & list of projects
      • Drug discovery
      • Translational research
      • Clinical trials
      • Registration & access
      • Treatments delivered
    • Advocacy
      • Open and collaborative R&D
      • Transparency of R&D costs
      • Pro-access policies and IP
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      • Gender equity
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      • Dengue Alliance
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      • LEAP Platform
      • redeLEISH Network
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Home

Research and development

We put neglected communities at the heart of drug R&D

Home

Research and development

We put neglected communities at the heart of drug R&D

Advancing medical innovation from laboratory bench to patient bedside

Our teams have been working since 2003 to address gaps in the traditional biomedical R&D system that lead to serious unmet medical needs for neglected patients. Acting as a ‘conductor of a virtual orchestra’, DNDi collaborates with research partners around the world at all stages of the R&D process. Together, we’ve discovered, developed, and delivered new treatments that reduce illness, suffering, and death from some of the world’s most neglected diseases.

Drug discovery

Translational research

Clinical trials

Registration and access

Project portfolio

We are working on more than 40 research and treatment access projects, including more than 20 focused on identifying or developing new chemical entities.

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Treatments delivered

We have delivered thirteen new treatments for six deadly diseases, saving millions of lives.

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Scientific articles

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Scientific articles
9 May 2025

Epidemiological, clinical and etiological treatment aspects in the Chagas clinic of the municipality of Comapa – Jutiapa, Guatemala

Acta Tropica
Scientific articles
15 May 2025

Quantitative analysis of DNDI-6174 using UPLC-MS/MS: A preclinical target site pharmacokinetic study

Journal of Chromatography B
Scientific articles
13 May 2025

Pharmacokinetic-pharmacodynamic modeling of benznidazole and its antitrypanosomal activity in a murine model of chronic Chagas disease

PLOS Neglected Tropical Diseases
Scientific articles
9 May 2025

Efficient constitution of a library of rotenoid analogs active against Trypanosoma cruzi from a digitalized plant extract collection

RSC Advances
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Target product profiles (TPPs)

TPPs serve to ensure that all products are designed from the start for the people and places that need them by describing the ideal specifications needed for a treatment.

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Events

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15-20 June 2025

Kigali, Rwanda

Twelfth EDCTP Forum

15-18 June 2025

Manila, Philippines

8th Asia Dengue Summit

22 May 2025

Online event

MSF Scientific Days

21 May 2025, 9-10:30 AM

Geneva, Switzerland

Scaling impact: Climate & health solutions that drive change

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