Selecting for success in the field: The target product profile
As a prerequisite to building a portfolio strategy, the desired R&D outcome for each disease is defined as the target product profile (TPP). Each R&D project in the portfolio is selected, progressed, and managed according to well-defined decision matrices based on these TPPs.
Used properly, the TPP can play a central role in the entire drug discovery and development process. This role includes effective optimization of drug candidates, decision-making within an organization, design of clinical research strategies, and constructive communication with regulatory authorities.
Characteristics of a target product profile
- Indications: Which diseases?
- Population: Which patients and where?
- Clinical Efficacy: Does it kill the parasite effectively?
- Safety and Tolerability: What kind and how many adverse events?
- Stability: How long can it be stored in the field?
- Route of Administration: How is it given to patients?
- Dosing Frequency: How often and how long must it be given?
- Cost: Will it be affordable to target population?
- Time to Availability: How long will it take to develop?
Our target product profiles
Making medical history for neglected patients
We develop urgently needed treatments for neglected patients and ensure they’re affordable, available, and adapted to the communities who need them
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