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Home > Our people > Leadership > R&D
CharlesMowbray2019

Dr Charles Mowbray

Discovery Director, DNDi

  • Charles Mowbray

Dr Mowbray joined DNDi in August 2011 with responsibility for lead optimization in drug discovery projects.

Prior to joining DNDi, Dr Mowbray spent 19 years at Pfizer Worldwide Research and Development where he was most recently a Research Fellow in Worldwide Medicinal Chemistry at the Sandwich Laboratories, UK.  During this time he developed experience as a medicinal chemist, project leader and people manager.  He has delivered projects across many disease areas, target classes and medicinal chemistry strategies and from target selection through to clinical candidate delivery. Two of these molecules have completed Phase IIb clinical studies.

Dr Mowbray was awarded his PhD by the University of Exeter and completed postdoctoral fellowships at the University of British Columbia and the University of Nottingham.

Featured news & publications

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  • Quantitative analysis of DNDI-6174 using UPLC-MS/MS: A preclinical target site pharmacokinetic study
  • Discovery and early optimization of 1H-indole-2-carboxamides with anti-Trypanosoma cruzi activity
  • Drugmakers tap AI to develop new treatments
  • Development and validation of ultra-performance liquid chromatography tandem mass spectrometry methods for the quantitative analysis of the antiparasitic drug DNDI-6148 in human plasma and various mouse biomatrices
  • Immunotherapeutic strategies as potential treatment options for cutaneous leishmaniasis
  • The case for a global therapeutics development coalition: Building a therapeutics pipeline for pandemic and endemic diseases
  • Synthesis and anti-Trypanosoma cruzi activity of 3-cyanopyridine derivatives
  • Further preclinical characterization of molnupiravir against SARS-CoV-2: Antiviral activity determinants and viral genome alteration patterns
  • Generation and evaluation of protease inhibitor-resistant SARS-CoV-2 strains
  • Bioluminescence imaging reveals enhanced SARS-CoV-2 clearance in mice with combinatorial regimens

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  • Drug Discovery Africa 2025
  • LCI Symposium 2025
  • GHIT R&D Forum 2024
  • 5th Iberoamerican Symposium on Organic Chemistry (SIBEAQO-V)
  • EFMC-ISMC 2024

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