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Home > Diseases

Cryptococcal meningitis

Our R&D portfolio for cryptococcal meningitis

Home > Diseases

Cryptococcal meningitis

Our R&D portfolio for cryptococcal meningitis

  • Overview
  • Facts
  • Projects & achievements

What we have achieved

We have joined a broad network of partner organizations, the Cryptococcal Meningitis Action Group, advocating for better access to life-saving treatment combinations for people with cryptococcal meningitis. Ending cryptococcal meningitis deaths by 2030 is its overarching goal.

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What we are doing for people living with cryptococcal meningitis

Our aim is to facilitate the scale-up of key medicines in selected, trailblazer African low- and middle-income countries through a comprehensive action plan. We are also working to develop a better formulation of the existing medicines.

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Translational research

Sustained release 5FC

An improved formulation of a key medicine. We are developing a formulation of an HIV-related cryptococcal meningitis medicine that can be taken orally or through a nasogastric tube. The medicine only needs to be taken twice a day rather than four times a day.

Registration & access

Immediate-release flucytosine & liposomal amphotericin B access

Address the supply and demand barriers limiting access to immediate-release flucytosine and liposomal amphotericin B for cryptococcal meningitis in low- and middle-income countries.

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Registration & access

2-in-1 LPV/r pellets and ABC/3TC or AZT/3TC

Registration & access

4-in-1 (ABC/3TC/LPV/r)

Translational research

Sustained release 5FC

Clinical trials

Acoziborole

Drug discovery

Aminopyrazoles

Translational research

Anfoleish (CL)

Clinical trials

ANTICOV

Drug discovery

Antiprotozoal activity profiling of approved drugs: a starting point toward drug repositioning

Registration & access

ASAQ

Registration & access

ASMQ

Translational research

Azoles E1224

Translational research

Chagas biomarkers

Translational research

CC6166

Drug discovery

Celgene Global Health visceral leishmaniasis series 1

Drug discovery

CF series

Registration & access

Chagas Access Project

Drug discovery

Chagas C205 series

Drug discovery

Chagas Hit-to-lead

Drug discovery

Moonshot

Translational research

CpG-D35 for cutaneous leishmaniasis

Drug discovery

Daiichi Sankyo Hit-to-lead for leishmaniasis

Drug discovery

Daiichi Sankyo series

Drug discovery

Development and validation of a novel Leishmania screening cascade

Drug discovery

DNDi Screening of the MMV Open Access Malaria Box for HAT, VL, and Chagas disease

Translational research

DNDI-0690

Drug discovery

DNDI-5421 & DNDI-5610

Translational research

DNDI-5561

Translational research

DNDI-6148

Translational research

DNDI-6148 Chagas disease

Translational research

DNDI-6174

Translational research

Emodepside

Translational research

Fenarimol

Registration & access

Fexinidazole for T.b. gambiense

Clinical trials

Fexinidazole for T.b. rhodesiense

Translational research

Fexinidazole for Chagas

Translational research

Fexinidazole/Miltefosine Combination (VL)

Translational research

Flubendazole Macrofilaricide

Clinical trials

Fosravuconazole

Clinical trials

Generic AmBisome

Translational research

GSK3186899/DDD853651 & GSK3494245/DDD1305143

Drug discovery

Guides to free computational chemistry tools for drug discovery

Registration & access

Hepatitis C Screening in Malaysia – #MYMissingMillions

Drug discovery

Hit-to-lead broad-spectrum antivirals for COVID-19

Registration & access

Immediate-release flucytosine & liposomal amphotericin B access

Drug discovery

iNTRODB

Translational research

K777 (Chagas)

Drug discovery

Leishmaniasis hit-to-lead

Drug discovery

Leishmaniasis L205 series

Clinical trials

Miltefosine + Paramomycin combination (Africa)

Drug discovery

MycetOS

our r&d portfolio

Making medical history for neglected patients

We develop urgently needed treatments for neglected patients and ensure they’re affordable, available, and adapted to the communities who need them

Doctor diagnosing a man in a village with his hands on the man's neck

Sleeping sickness

Transmitted by the bite of a tsetse fly and causes severe neurological disorders

We delivered a revolutionary new drug to replace toxic treatments, and have ongoing trials to eliminate this disease

Young boy sitting on a hospital bed being examined by a nurse

Chagas disease

Causes heart and vital organ damage, after people are bitten by blood-sucking bugs

We delivered the first-ever treatment for children; now we’re searching for new drug candidates and working to boost access to care

Girl with skin lesions on her nose

Cutaneous leishmaniasis

Leaves disfiguring, life-long scars that lead to severe social stigma

We’re working to develop safer, shorter treatments for this disabling disease

Young man standing in the street

Hepatitis C

Millions are left without treatment even though effective drugs exist

We’ve delivered a treatment as simple, safe, and effective as the best drugs available today – at a fraction of the cost 

Girl looking over a fence

Visceral leishmaniasis

Is one of the world’s biggest parasitic killers, spread by the bites of sandflies

We’re working to develop a new generation of treatments to replace drugs that are painful, ineffective, and cause side effects

Healthcare workers in a hospital

COVID-19

Devasting and deadly to many, there’s too little research to help the most vulnerable

We’re accelerating research by coordinating clinical trials in low-resource settings and bringing together partners

Father walking in rural village with a cane and holding his son's hand

Filaria: river blindness

Lead to unbearable itching, disfiguring skin lesions, and even blindness

We’re working to develop a safe, effective, and affordable drug for the prevention and treatment of this debilitating disease

Patient medical examination

Cryptococcal meningitis

Without treatment, deadly for thousands of people with advanced HIV

We’re working to improve access to life-saving treatments and developing an easier-to-use formulation

Sleeping sickness

Chagas disease

Cutaneous leishmaniasis

Hepatitis C

Visceral leishmaniasis

COVID-19

Filaria: river blindness

Cryptococcal meningitis

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