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Home > Diseases
Mosquito icon

Dengue

Creating a global partnership to tackle a rapidly spreading climate-sensitive disease

Home > Diseases
Mosquito icon

Dengue

Creating a global partnership to tackle a rapidly spreading climate-sensitive disease

  • Overview
  • Facts

We are partnering with dengue-endemic countries to find a safe, affordable, and effective treatment for dengue. Through this global collaboration we are working on joint projects to advance the pre-clinical development of new drug candidates and run clinical trials to test the most promising ones.

Dengue is mostly spread by the bite of the Aeades aegypti mosquito. Some people have no symptoms, but dengue can also cause flu-like symptoms including fever, nausea, vomiting, rashes, eye pain and muscle, joint, or bone pain. There are no specific drugs to treat dengue, and there is only limited use of vaccines. The lack of treatment options increases the risk of developing severe dengue – which is potentially fatal.

Dengue is the most widely distributed and rapidly spreading mosquito-borne viral disease in the world, fuelled by climate change, rapid urbanization and population growth. Dengue is classified by the World Health Organization as one of the top ten threats to public health.

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‘It’s everywhere and there’s nothing we can do about it.’

Tan Jhii Lian, infected by dengue twice in just three months in Malacca, Malaysia
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What we have achieved

We are bringing together partners in dengue-endemic countries to find urgently needed treatments for dengue.

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Dengue Alliance

Launched in 2022, the Dengue Alliance is a global partnership led by institutions from dengue-endemic countries and DNDi that aims to develop affordable and accessible treatments for dengue.

What we’re doing for people with dengue

Together with our partners, we have started preclinical studies and will be starting clinical trials aiming to deliver an affordable and accessible treatment within five years. We are also working together on diagnostics and regulatory and access strategies, as well as jointly raising funds and mobilizing resources.

Read more in our Annual Report
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Translational research

Dengue pre-clinical profiling

DNDi and our partners are prioritizing drug development for dengue with a focus on pregnant women, young children, and people with comorbidities. In the short term, we are working to repurpose existing direct-acting antivirals and host-directed therapies. Our aim over the medium term is to develop all-new antivirals.

Registration & access

Dengue seroprevalence / burden studies

DNDi and partners will undertake a retrospective dengue seroprevalence study in Senegal and in selected cities in Ghana and DRC. A second element of this project is to update the global burden of dengue, including new estimates from the surveys in Africa and other estimates generated after literature review.

Drug discovery

AI-guided discovery

Scientists from DNDi and BenevolentAI use an artificial intelligence-driven approach to interrogate the underlying mechanisms involved in dengue and rapidly identify therapies that could be repurposed to prevent progression to severe dengue.

Dengue news & resources

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Making medical history for neglected patients

We develop urgently needed treatments for neglected patients and ensure they’re affordable, available, and adapted to the communities who need them

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Chagas disease

Causes heart and vital organ damage, after people are bitten by blood-sucking bugs

We delivered the first-ever treatment for children; now we’re searching for new drug candidates and working to boost access to care

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Cryptococcal meningitis

Without treatment, deadly for thousands of people with advanced HIV

We’re working to improve access to life-saving treatments and developing an easier-to-use formulation

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Cutaneous leishmaniasis

Leaves disfiguring, life-long scars that lead to severe social stigma

We’re working to develop safer, shorter treatments for this disabling disease

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Dengue

Rapidly spreading climate-sensitive disease with no specific treatment

We’re building a global partnership with dengue-endemic countries to develop a first treatment

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Filaria: river blindness

Lead to unbearable itching, disfiguring skin lesions, and even blindness

We’re working to develop a safe, effective, and affordable drug for the prevention and treatment of this debilitating disease

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Hepatitis C

Millions are left without treatment even though effective drugs exist

We’ve delivered a treatment as simple, safe, and effective as the best drugs available today – at a fraction of the cost 

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Mycetoma

Often ends in amputation​, after people get infected from stepping on a thorn

We conducted the world’s first trial for an alternative to current treatments, which are toxic and difficult to administer

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Paediatric HIV

Without treatment, half of children die before their second birthday

We’ve developed a strawberry-flavoured treatment to meet the needs of children long neglected by the global HIV response

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Pandemic Preparedness

The COVID-19 pandemic intensified global health inequalities

We’re bringing together partners and accelerating research to prepare for future viral pandemics in low-resource settings

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Sleeping sickness

Transmitted by the bite of a tsetse fly and causes severe neurological disorders

We delivered a revolutionary new drug to replace toxic treatments, and have ongoing trials to eliminate this disease

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Visceral leishmaniasis

Is one of the world’s biggest parasitic killers, spread by the bites of sandflies

We’re working to develop a new generation of treatments to replace drugs that are painful, ineffective, and cause side effects

Chagas disease

Cryptococcal meningitis

Cutaneous leishmaniasis

Dengue

Filaria: river blindness

Hepatitis C

Mycetoma

Paediatric HIV

Pandemic Preparedness

Sleeping sickness

Visceral leishmaniasis

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