by Gupta S, Yardley V, Vishwakarma P, Shivahare R, Sharma B, Launay D, Martin D, Puri SK. Journal of Antimicrobial Chemotherapy 2014, doi:10.1093/jac/dku422.
Summary: Nitroimidazoles are a class of compounds with known antimicrobial activity against various parasites, including kinetoplastids. A selected library of 72 nitroimidazo-oxazoles was evaluated for their anti-leishmanial activity, and led to the identification of DNDI-VL-2098 as a preclinical candidate for further drug development as an oral treatment for VL.
