by Gillon J-Y, Delhomme S, Launay D, Blesson S, Braillard S, Maghdooni P, Assmus F, Hoglund R, Tarning J, Loyau S, Arana B, Latreille-Barier M, Donazzolo Y. British Journal of Clinical Pharmacology 2025;1-11. doi: 10.1002/bcp.70328
Summary: The benzoxaborole derivative DNDI-6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. The authors of this manuscript investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI-6148 in a randomized, parallel-group, placebo-controlled, first-in-human study. No major safety concerns were identified in 64 healthy male participants exposed to an oral suspension of DNDI-6148 at single doses up to 380 mg, or placebo, and the PK profile was favourable. These data support further clinical development.
