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Home > Research and development > Portfolio

Visceral leishmaniasis 

Leishmaniasis L205 series

objective

Progress a compound from the 205 series towards candidate selection and nomination for further pre-clinical development for visceral leishmaniasis.

project start
2017
project status
Completed

last phase of drug development

Discovery project phase
Drug Discovery
Translation project phase
Translational research
clinical trials icon
Clinical trials
Treatment Access
Registration & access

updated 29 Feb 2020

Following proof-of-principle with the 205 series for visceral leishmaniasis, compounds from this series have shown a 100% parasite load reduction in liver and spleen in a visceral leishmaniasis murine model. Further characterization of this series is ongoing.

Project updates

2019

Following the assessment of the three lead compounds from this series (DNDI-6588, DNDI-6749, and DNDI-6174), DNDI-6174 was progressed and nominated as a pre-clinical candidate for visceral leishmaniasis.

2018

Lead compound DNDI-6588 showed great efficacy in vivo in both mouse and hamster models for visceral leishmaniasis. Additional 205-series compounds having similar or improved profiles have been added to the candidate shortlist and are currently being assessed.

2017

Over 400 compounds have been synthesized to date in this lead optimization programme for Chagas disease and leishmaniasis.

Partners & service providers

  • AbbVie, USA
  • BioAster, France
  • Charles River Laboratories (formerly WIL Research), France
  • Epichem, Australia
  • Eurofins CEREP, France
  • Eurofins Panlabs, USA
  • Griffith University, Australia
  • London School of Hygiene & Tropical Medicine (LSHTM), UK
  • Monash University, Centre for Drug Candidate Optimisation (CDCO), Australia
  • University of Antwerp, Laboratory of Microbiology, Parasitology, and Hygiene (LMPH), Belgium
  • WuXi AppTech, China
​

Funding

  • Germany - Federal Ministry of Education and Research (BMBF) through KfW
  • Switzerland - Swiss Agency for Development and Cooperation (SDC)
  • The Netherlands - Dutch Ministry of Foreign Affairs (DGIS)
  • UK - UK International Development
​
  • Médecins Sans Frontières International
​

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