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Home > Research and development > Portfolio

Chagas disease 

Fenarimol

objective

Non-regulatory pre-clinical review

project start
2011
project status
Completed

last phase of drug development

Discovery project phase
Drug Discovery
Translation project phase
Translational research
clinical trials icon
Clinical trials
Treatment Access
Registration & access

updated 30 Sep 2014

Two interesting candidates from the fenarimol series of compounds were identified through lead optimization efforts. In 2013, the project was in its non-regulatory preclinical phase, with further profiling of candidates, before nominating one candidate for progression into regulatory pre-clinical development. The objective was to perform Good Laboratory Practice (GLP) safety studies, as well as Chemistry, Manufacturing, and Control (CMC) studies on the selected candidate compound, in order to file a formal investigational new drug (IND) application and move the candidate to first-in-man studies. However, given the lack of sustained efficacy of azoles (E1224 and posaconazole) in clinical trials for Chagas diseases, this project has been stopped.

Partners & service providers

  • Epichem, Australia
  • Federal University of Ouro Preto (UFOP), Brazil
  • Institut Pasteur Korea (IPK), Republic of Korea
  • Monash University, Centre for Drug Candidate Optimisation (CDCO), Australia
  • Murdoch University, Australia
​

Funding

  • Germany - Federal Ministry of Education and Research (BMBF) through KfW
  • Spain - Spanish Agency for International Development Cooperation (AECID)
  • Switzerland - Swiss Agency for Development and Cooperation (SDC)
  • The Netherlands - Dutch Ministry of Foreign Affairs (DGIS)
  • UK - UK International Development
  • USA - National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID)
​
  • Médecins Sans Frontières International
  • Other private foundations and individuals
​

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