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Home > Our people > Leadership > R&D
Jean-Robert Ioset

Jean-Robert Ioset PhD

Discovery Leader, DNDi

Jean-Robert Ioset joined DNDi in 2005 and currently serves as Discovery Leader at the Drugs for Neglected Diseases initiative in Geneva.

Jean-Robert is a pharmacist by training and holds a PhD in Pharmaceutical Sciences from the University of Lausanne, Switzerland, as well as additional qualifications in tropical medicine, public health, and management of medtech, biotech, and pharma ventures.

Jean-Robert has over 15 years of experience in anti-infective drug discovery, focusing on neglected diseases such as human African trypanosomiasis, leishmaniases, Chagas disease, as well as mycetoma and emerging viral diseases. He oversees DNDi’s global early discovery portfolio and manages its screening network, collaborating with academic, pharmaceutical, and biotechnology partners worldwide. His leadership has been central to the identification and development of novel compounds, with more than 4 million chemical entities screened to date. In addition to his research and R&D responsibilities, Jean-Robert is actively engaged in business development, legal, communications, advocacy, and fundraising efforts for DNDi discovery programmes. He has authored over 70 publications in the field.

Featured news & publications

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  • Efficient constitution of a library of rotenoid analogs active against Trypanosoma cruzi from a digitalized plant extract collection
  • Challenges and advancements in the development of vaccines and therapies against Chagas disease
  • A sample-centric and knowledge-driven computational framework for natural products drug discovery
  • Madurastatins with imidazolidinone rings: Natural products or side-reaction products from extraction solvents?
  • Need for a standardized translational drug development platform: Lessons learned from the repurposing of drugs for COVID-19
  • Novel oxaborole, nitroimidazole, and aminopyrazoles with activity against experimental cutaneous leishmaniasis
  • Addressing the most neglected diseases through an open research model: the discovery of fenarimols as novel drug candidates for eumycetoma
  • Phenotypic screening approaches for Chagas disease drug discovery
  • Evaluation of parameters impacting drug susceptibility in intracellular T. cruzi assay protocols
  • Assessing anti-T. cruzi candidates in vitro for sterile cidality

Featured events

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  • BrazMedChem 2025
  • The 65th annual meeting of the Korean Society for Parasitology and Tropical Medicine
  • Advancing neglected diseases drug discovery in endemic areas
  • ISCNP31 and ICOB11

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