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Home > Diseases
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Parasitic worms

Developing missing cures for disabling and stigmatizing diseases

Home > Diseases
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Parasitic worms

Developing missing cures for disabling and stigmatizing diseases

Caused by parasitic worms and most common in tropical and subtropical regions, river blindness, lymphatic filariasis, and schistosomiasis affect millions of people worldwide. They take their greatest toll on people affected by poverty, malnutrition, and poor sanitation and housing – and can cause debilitating illness, social exclusion, long-term disability and, in severe cases, death. 

There are no cures for neglected parasitic worm diseases. Current strategies to control their spread mostly rely on the mass administration of anthelminthic drugs that must be administered to nearly all people in endemic areas for five to ten consecutive years.

What we’re doing for parasitic worm diseases

We are joining forces with partners to develop new treatments that can cure parasitic worm diseases before they cause lasting harm – and working to make sure they are suitable for all people who need them, including young children and pregnant women. 

River blindness

Causes vision loss and eventually permanent blindness if left untreated.

Schistosomiasis

Can cause organ damage and long-term reproductive harm – especially for women and girls.

Lymphatic filariasis

Causes painful and disabling swelling of the limbs requiring continuous medical care.

River blindness

Schistosomiasis

Lymphatic filariasis

Parasitic worm diseases news & resources

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News
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News
3 Oct 2025

DNDi 2025 Projects of the Year recognize contributions of DNDi teams and partners working to deliver urgently needed innovations for people affected by Chagas disease and river blindness

Press releases
15 Sep 2025

Switzerland renews commitment to DNDi to advance medical innovation for neglected patients 

Publications
2 Sep 2025

DNDi Brochure

Publications
15 Jul 2025

DNDi 2024 Annual Report

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Making medical history for neglected patients

We develop urgently needed treatments for neglected patients and ensure they’re affordable, available, and adapted to the communities who need them

Chagas disease

Causes heart and vital organ damage, after people are bitten by blood-sucking bugs

We delivered the first-ever treatment for children; now we’re searching for new drug candidates and working to boost access to care

Patient medical examination

Cryptococcal meningitis

Without treatment, deadly for thousands of people with advanced HIV

We’re working to improve access to life-saving treatments and developing an easier-to-use formulation

Cutaneous leishmaniasis

Leaves disfiguring, life-long scars that lead to severe social stigma

We’re working to develop safer, shorter treatments for this disabling disease

Dengue

Rapidly spreading climate-sensitive disease with no specific treatment

We’re building a global partnership with dengue-endemic countries to develop a first treatment

Hepatitis C

Millions are left without treatment even though effective drugs exist

We’ve delivered a treatment as simple, safe, and effective as the best drugs available today – at a fraction of the cost 

Mycetoma

Often ends in amputation​, after people get infected from stepping on a thorn

We conducted the world’s first trial for an alternative to current treatments, which are toxic and difficult to administer

Paediatric HIV

Without treatment, half of children die before their second birthday

We’ve developed a strawberry-flavoured treatment to meet the needs of children long neglected by the global HIV response

Healthcare workers in a hospital

Pandemic Preparedness

COVID-19 threw longstanding global health injustices into stark relief

We’re conducting research for new drugs before the next pandemic strikes and advocating for equitable innovation and access

Parasitic worms

Cause debilitating illness, social exclusion, and long-term disability

We’re working across multiple diseases to develop missing cures that can prevent lasting harm

Sleeping sickness

Transmitted by the bite of a tsetse fly and causes severe neurological disorders

We delivered a revolutionary new drug to replace toxic treatments, and have ongoing trials to eliminate this disease

Chagas disease

Cryptococcal meningitis

Cutaneous leishmaniasis

Dengue

Hepatitis C

Mycetoma

Paediatric HIV

Pandemic Preparedness

Parasitic worms

Sleeping sickness

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