DNDI-5561
Progress DNDi-5561, a selected aminopyrazole compound, to Phase I clinical trials and realize some activities including formulation development, drug product manufacture and start single ascending dose stage of first-in-human.
last phase of drug development
updated 31 Aug 2019
DNDI-5561 is the most advanced compound of the aminopyrazole series. DNDi developed the series from a single high-throughput screening hit, which was originally identified in an in vitro screen of Pfizer’s compound library. A hit-to-lead project conducted by DNDi produced improved leads with activity in animal models of leishmaniasis. The optimization of these leads to produce DNDI-5561 was achieved in a partnership between DNDi, Takeda Pharmaceutical Company Limited, and the GHIT Fund.
Project updates
2019
Due to unfavourable safety results in pre-clinical studies, the decision was made to stop development of DNDI-5561 in 2019.
2018
Pre-clinical studies to enable a first-in-human study (Phase I) started in February 2018 and should be completed by the end of 2019
2017
Following positive results of efficacy and safety studies in animal model, DNDI-5561 was selected as pre-clinical candidate in October 2017.
Stay connected
Get our latest news, personal stories, research articles, and job opportunities.
