by Guidi M, Mercier T, Aouri M, Decosterd LA, Csajka C, Ogutu B, Carn G, Kiechel JR. Malaria Journal 2019, 18:139, doi:10.1186/s12936-019-2754-6.

Summary: WHO has recommended reconsideration of the use of ASMQ in Africa, where it is not frequently used due to perceived poor tolerance of mefloquine. In a large clinical study, the pharmacokinetics of a fixed dose combination of ASMQ was investigated in an African paediatric population. A subset of 50 Kenyan children from this trial underwent intensive sampling to develop population pharmacokinetic models for AS, its metabolite dihydroartemisinin (DHA) and MQ. Body weight was shown to be the largest contributor to variability in drug exposure. This is accommodated for by the ASMQ fixed dose combination dosing recommendation; beyond this there is no indication that the dosage should be modified in children with malaria compared to adults.

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by Sirima BS, Ogutu B, Lusingu JPA, Mtoro A, Mrango Z, Ouedraogo A, Yaro JB, Onyango KO, Gesase S, Mnkande E, Ngocho JS, Ackermann I, Aubin F, Vanraes J, Strub N, Carn G. The Lancet Infectious Diseases 2016, doi:10.1016/S1473-3099(16)30020-2.

Summary: WHO recommends combinations of an artemisinin derivative plus an antimalarial drug of longer half-life as treatment options for uncomplicated Plasmodium falciparum infection. In Africa, artemether-lumefantrine is the most widely used artemisinin-based combination therapy, whereas artesunate–mefloquine is used infrequently because of a perceived poor tolerance to mefloquine. WHO recommends reconsideration of the use of artesunate–mefloquine in Africa. We compared the efficacy and safety of fixed-dose artesunate–mefloquine with that of artemether–lumefantrine for treatment of children younger than 5 years with uncomplicated P falciparum malaria.

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by Petit C, Jullien V, Samson A, Guedj J, Kiechel JR, Zohar S, Comets E. Antimicrobial Agents Chemotherapy 2015. 60(3):1481-91. doi: 10.1128/AAC.01125-15.

Summary: The aims of this study was to design a pharmacokinetic (PK) study by using information about adults and to evaluate the robustness through a case study of mefloquine. PK data on adults and children from two studies using artesunate-mefloquine was used. Although the extrapolated model did not predict the observed mefloquine concentrations in children very accurately, it allowed precise and unbiased estimates across various model assumptions, contrary to the empirical design. Using information from adult studies combined with allometry and maturation can help provide robust designs for pediatric studies.

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by Olaosebikan R, Ernest K, Bojang K, Mokuolu O, Rehman AM, Affara M, Nwakanma D, Kiechel JR, Ogunkunle T, Olagunju T, Murtala R, Omefe P, Lambe T, Bello S, Ibrahim O, Olorunsola B, Ojuawo A, Greenwood B, Milligan P. The Journal of Infectious Diseases 2015, doi: 10.1093/infdis/jiv093.

Summary: Malaria prophylaxis is recommended for persons with sickle-cell disease but the value of this has been questioned. The aim of this study was to find out if intermittent preventive treatment with ASMQ FDC or sulfadoxine-pyrimethamine plus amodiaquine was more effective than daily proguanil for malaria prevention in subjects with sickle cell disease. Intermittent preventive treatment  with ASMQ administered when sickle-cell disease patients come for routine clinic visits was well tolerated and more effective in preventing malaria than daily prophylaxis with proguanil.

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by Jullien V, Valecha N, Srivastava B, Sharma B, Kiechel JR. Malaria Journal 2014, doi:10.1186/1475-2875-13-187.

 

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by Valecha N, Srivastava B, Dubhashi NG, Krishnamoorthy Rao BH, Kumar A, Ghosh SK, Narayan Singh JK, Kiechel JR, Shar Bma, Jullien V, Dash AP, Taylor WRJ & Anvikar AR. J Vector Borne Dis, December 2013

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by Leang R, Ros S, Duong S, Navaratnam V, Lim P, Ariey F, Kiechel JR, Ménard D and Taylor WRJ. Malaria Journal, September 2013.

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by Wells SDiap G, and Kiechel JR. Malaria Journal, February 2013.

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by Santelli AC, Ribeiro I, Daher A, Boulos M, Marchesini PB, La Corte dos Santos R, Lucena MB, Magalhães I, Leon AP, Junger W, and Ladislau JL. Malaria Journal, 11:286, August 2012.

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by Krudsood S, Looareesuwan S, Wilairatama P, Leowattana W, Tangpukdee N, Chalermrut K, Ramanathan S, Navaratnam V, Olliaro P, Vaillant M, Kiechel JR, Taylor V.R.J. Tropical Medicine and International Health, January 2011. doi:10.1111/j.1365-3156.2010.02714.x. 

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